ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Acetylcholine receptor subunit alpha

Intramolecular
Cysteine 148 and cysteine 162
Cysteine 212 and cysteine 213
A redox-regulated disulphide may form within Acetylcholine receptor subunit alpha between cysteines 148 and 162 (128 and 142 respectively in this structure).

Details

Redox score ?
85
PDB code
2qc1
Structure name
crystal structure of the extracellular domain of the nicotinic acetylcholine receptor 1 subunit bound to alpha-bungarotoxin at 1
Structure deposition date
2007-06-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
P04756
Residue number A
148
Residue number B
162
Peptide name
Acetylcholine receptor subunit alpha

Ligandability

Cysteine 148 of Acetylcholine receptor subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 162 of Acetylcholine receptor subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Acetylcholine receptor subunit alpha between cysteines 212 and 213 (192 and 193 respectively in this structure).

Details

Redox score ?
83
PDB code
5hbv
Structure name
complex structure of fab35 and mouse nachr alpha1
Structure deposition date
2016-01-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
48
Minimum pKa ?
nan
% buried
nan
Peptide accession
P04756
Residue number A
212
Residue number B
213
Peptide name
Acetylcholine receptor subunit alpha

Ligandability

Cysteine 212 of Acetylcholine receptor subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 213 of Acetylcholine receptor subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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