a tool for identifying drug-targetable redox-active disulphides

C-reactive protein

Intramolecular

Cysteine 54 and cysteine 115

A redox-regulated disulphide may form within C-reactive protein between cysteines 54 and 115 (36 and 97 respectively in this structure).

Details

Redox score ?

80

PDB code

Structure name

monoclinic form of human c-reactive protein

Structure deposition date

2010-12-07

Thiol separation (Å)

2

Half-sphere exposure sum ?

84

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

54

Residue number B

115

Peptide name

C-reactive protein

Ligandability

Cysteine 54 of C-reactive protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 115 of C-reactive protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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