a tool for identifying drug-targetable redox-active disulphides

Serum amyloid P-component

Intramolecular

Cysteine 55 and cysteine 114

A redox-regulated disulphide may form within Serum amyloid P-component between cysteines 55 and 114 (36 and 95 respectively in this structure).

Details

Redox score ?

70

PDB code

Structure name

structure of cphpc bound to serum amyloid p component

Structure deposition date

2012-05-29

Thiol separation (Å)

4

Half-sphere exposure sum ?

90

Minimum pK_a ?

6

% buried

100

Peptide accession

Residue number A

55

Residue number B

114

Peptide name

Serum amyloid P-component

Ligandability

Cysteine 55 of Serum amyloid P-component

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 114 of Serum amyloid P-component

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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