ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Beta-2-glycoprotein 1

Intramolecular
Cysteine 174 and cysteine 200
Cysteine 307 and cysteine 345
Cysteine 110 and cysteine 137
Cysteine 23 and cysteine 66
Cysteine 51 and cysteine 79
Cysteine 205 and cysteine 248
Cysteine 264 and cysteine 315
Cysteine 84 and cysteine 124
Cysteine 234 and cysteine 260
Cysteine 142 and cysteine 188
More...
Cysteine 300 and cysteine 325
Cysteine 325 and cysteine 345
Cysteine 300 and cysteine 345
A redox-regulated disulphide may form within Beta-2-glycoprotein 1 between cysteines 174 and 200 (155 and 181 respectively in this structure).

Details

Redox score ?
89
PDB code
7kg4
Structure name
recombinant beta-2-glycoprotein i antibody recognition loop mutant
Structure deposition date
2020-10-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
P02749
Residue number A
174
Residue number B
200
Peptide name
Beta-2-glycoprotein 1

Ligandability

Cysteine 174 of Beta-2-glycoprotein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 200 of Beta-2-glycoprotein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Beta-2-glycoprotein 1 between cysteines 307 and 345 (288 and 326 respectively in this structure).

Details

Redox score ?
88
PDB code
6v08
Structure name
crystal structure of human recombinant beta-2 glycoprotein i (hrb2gpi)
Structure deposition date
2019-11-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P02749
Residue number A
307
Residue number B
345
Peptide name
Beta-2-glycoprotein 1

Ligandability

Cysteine 307 of Beta-2-glycoprotein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 345 of Beta-2-glycoprotein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Beta-2-glycoprotein 1 between cysteines 110 and 137 (91 and 118 respectively in this structure).

Details

Redox score ?
87
PDB code
7kg4
Structure name
recombinant beta-2-glycoprotein i antibody recognition loop mutant
Structure deposition date
2020-10-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
P02749
Residue number A
110
Residue number B
137
Peptide name
Beta-2-glycoprotein 1

Ligandability

Cysteine 110 of Beta-2-glycoprotein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 137 of Beta-2-glycoprotein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Beta-2-glycoprotein 1 between cysteines 23 and 66 (4 and 47 respectively in this structure).

Details

Redox score ?
87
PDB code
7kg4
Structure name
recombinant beta-2-glycoprotein i antibody recognition loop mutant
Structure deposition date
2020-10-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
P02749
Residue number A
23
Residue number B
66
Peptide name
Beta-2-glycoprotein 1

Ligandability

Cysteine 23 of Beta-2-glycoprotein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 66 of Beta-2-glycoprotein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Beta-2-glycoprotein 1 between cysteines 51 and 79 (32 and 60 respectively in this structure).

Details

Redox score ?
87
PDB code
7kg4
Structure name
recombinant beta-2-glycoprotein i antibody recognition loop mutant
Structure deposition date
2020-10-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
P02749
Residue number A
51
Residue number B
79
Peptide name
Beta-2-glycoprotein 1

Ligandability

Cysteine 51 of Beta-2-glycoprotein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 79 of Beta-2-glycoprotein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Beta-2-glycoprotein 1 between cysteines 205 and 248 (186 and 229 respectively in this structure).

Details

Redox score ?
87
PDB code
7kg4
Structure name
recombinant beta-2-glycoprotein i antibody recognition loop mutant
Structure deposition date
2020-10-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
P02749
Residue number A
205
Residue number B
248
Peptide name
Beta-2-glycoprotein 1

Ligandability

Cysteine 205 of Beta-2-glycoprotein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 248 of Beta-2-glycoprotein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Beta-2-glycoprotein 1 between cysteines 264 and 315 (245 and 296 respectively in this structure).

Details

Redox score ?
86
PDB code
7kg4
Structure name
recombinant beta-2-glycoprotein i antibody recognition loop mutant
Structure deposition date
2020-10-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
P02749
Residue number A
264
Residue number B
315
Peptide name
Beta-2-glycoprotein 1

Ligandability

Cysteine 264 of Beta-2-glycoprotein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 315 of Beta-2-glycoprotein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Beta-2-glycoprotein 1 between cysteines 84 and 124 (65 and 105 respectively in this structure).

Details

Redox score ?
86
PDB code
7kg4
Structure name
recombinant beta-2-glycoprotein i antibody recognition loop mutant
Structure deposition date
2020-10-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
P02749
Residue number A
84
Residue number B
124
Peptide name
Beta-2-glycoprotein 1

Ligandability

Cysteine 84 of Beta-2-glycoprotein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 124 of Beta-2-glycoprotein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Beta-2-glycoprotein 1 between cysteines 234 and 260 (215 and 241 respectively in this structure).

Details

Redox score ?
85
PDB code
7kg4
Structure name
recombinant beta-2-glycoprotein i antibody recognition loop mutant
Structure deposition date
2020-10-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
P02749
Residue number A
234
Residue number B
260
Peptide name
Beta-2-glycoprotein 1

Ligandability

Cysteine 234 of Beta-2-glycoprotein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 260 of Beta-2-glycoprotein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Beta-2-glycoprotein 1 between cysteines 142 and 188 (123 and 169 respectively in this structure).

Details

Redox score ?
85
PDB code
7kg4
Structure name
recombinant beta-2-glycoprotein i antibody recognition loop mutant
Structure deposition date
2020-10-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
P02749
Residue number A
142
Residue number B
188
Peptide name
Beta-2-glycoprotein 1

Ligandability

Cysteine 142 of Beta-2-glycoprotein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 188 of Beta-2-glycoprotein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Beta-2-glycoprotein 1 between cysteines 300 and 325 (281 and 306 respectively in this structure).

Details

Redox score ?
82
PDB code
7kg4
Structure name
recombinant beta-2-glycoprotein i antibody recognition loop mutant
Structure deposition date
2020-10-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
P02749
Residue number A
300
Residue number B
325
Peptide name
Beta-2-glycoprotein 1

Ligandability

Cysteine 300 of Beta-2-glycoprotein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 325 of Beta-2-glycoprotein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Beta-2-glycoprotein 1 between cysteines 325 and 345 (306 and 326 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
2kri
Structure name
structure of a complex between domain v of beta2-glycoprotein i and the fourth ligand-binding module from ldlr determined with haddock
Structure deposition date
2009-12-18
Thiol separation (Å)
10
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P02749
Residue number A
325
Residue number B
345
Peptide name
Beta-2-glycoprotein 1

Ligandability

Cysteine 325 of Beta-2-glycoprotein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 345 of Beta-2-glycoprotein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Beta-2-glycoprotein 1 between cysteines 300 and 345 (281 and 326 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
3op8
Structure name
crystal structure of the domain v from beta2-glycoprotein i
Structure deposition date
2010-08-31
Thiol separation (Å)
10
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
P02749
Residue number A
300
Residue number B
345
Peptide name
Beta-2-glycoprotein 1

Ligandability

Cysteine 300 of Beta-2-glycoprotein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 345 of Beta-2-glycoprotein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: