ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Platelet basic protein

Intermolecular
Cysteine 105 and cysteine 105
Cysteine 105 and cysteine 65
Intramolecular
Cysteine 63 and cysteine 89
Cysteine 65 and cysteine 89
Cysteine 63 and cysteine 65
Cysteine 89 and cysteine 105
Cysteine 63 and cysteine 105
A redox-regulated disulphide may form between two units of Platelet basic protein at cysteines 105 and 105 (67 and 67 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
1nap
Structure name
the crystal structure of recombinant human neutrophil-activating peptide-2 (m6l) at 1
Structure deposition date
1994-12-19
Thiol separation (Å)
9
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide A name
Platelet basic protein
Peptide B name
Platelet basic protein
Peptide A accession
P02775
Peptide B accession
P02775
Peptide A residue number
105
Peptide B residue number
105

Ligandability

A redox-regulated disulphide may form between two units of Platelet basic protein at cysteines 105 and 65 (67 and 27 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
1nap
Structure name
the crystal structure of recombinant human neutrophil-activating peptide-2 (m6l) at 1
Structure deposition date
1994-12-19
Thiol separation (Å)
9
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide A name
Platelet basic protein
Peptide B name
Platelet basic protein
Peptide A accession
P02775
Peptide B accession
P02775
Peptide A residue number
105
Peptide B residue number
65

Ligandability

Cysteine 105 of Platelet basic protein

Cysteine 65 of Platelet basic protein

A redox-regulated disulphide may form within Platelet basic protein between cysteines 63 and 89 (25 and 51 respectively in this structure).

Details

Redox score ?
90
PDB code
1f9p
Structure name
crystal structure of connective tissue activating peptide-iii(ctap- iii) complexed with polyvinylsulfonic acid
Structure deposition date
2000-07-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
47
Minimum pKa ?
nan
% buried
nan
Peptide accession
P02775
Residue number A
63
Residue number B
89
Peptide name
Platelet basic protein

Ligandability

Cysteine 63 of Platelet basic protein

Cysteine 89 of Platelet basic protein

A redox-regulated disulphide may form within Platelet basic protein between cysteines 65 and 89 (27 and 51 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
1tvx
Structure name
neutrophil activating peptide-2 variant form m6l with five additional amino terminal residues (dsdly)
Structure deposition date
1996-11-05
Thiol separation (Å)
8
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
P02775
Residue number A
65
Residue number B
89
Peptide name
Platelet basic protein

Ligandability

Cysteine 65 of Platelet basic protein

Cysteine 89 of Platelet basic protein

A redox-regulated disulphide may form within Platelet basic protein between cysteines 63 and 65 (25 and 27 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
1nap
Structure name
the crystal structure of recombinant human neutrophil-activating peptide-2 (m6l) at 1
Structure deposition date
1994-12-19
Thiol separation (Å)
8
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
P02775
Residue number A
63
Residue number B
65
Peptide name
Platelet basic protein

Ligandability

Cysteine 63 of Platelet basic protein

Cysteine 65 of Platelet basic protein

A redox-regulated disulphide may form within Platelet basic protein between cysteines 89 and 105 (51 and 67 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
1tvx
Structure name
neutrophil activating peptide-2 variant form m6l with five additional amino terminal residues (dsdly)
Structure deposition date
1996-11-05
Thiol separation (Å)
10
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
P02775
Residue number A
89
Residue number B
105
Peptide name
Platelet basic protein

Ligandability

Cysteine 89 of Platelet basic protein

Cysteine 105 of Platelet basic protein

A redox-regulated disulphide may form within Platelet basic protein between cysteines 63 and 105 (25 and 67 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
1nap
Structure name
the crystal structure of recombinant human neutrophil-activating peptide-2 (m6l) at 1
Structure deposition date
1994-12-19
Thiol separation (Å)
10
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
P02775
Residue number A
63
Residue number B
105
Peptide name
Platelet basic protein

Ligandability

Cysteine 63 of Platelet basic protein

Cysteine 105 of Platelet basic protein

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