Platelet factor 4
Intermolecular
Cysteine 83 and cysteine 83
Cysteine 27 and cysteine 27
Cysteine 83 and cysteine 43
Cysteine 25 and cysteine 67
Intramolecular
Cysteine 41 and cysteine 67
Cysteine 43 and cysteine 67
Cysteine 41 and cysteine 43
Cysteine 67 and cysteine 83
Cysteine 41 and cysteine 83
1f9s B 152 C 252
A redox-regulated disulphide may form between two units of Platelet factor 4 at cysteines 83 and 83 (152 and 252 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
1f9s
Structure name
crystal structure of platelet factor 4 mutant 2
Structure deposition date
2000-07-11
Thiol separation (Å)
9
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide A name
Platelet factor 4
Peptide B name
Platelet factor 4
Peptide A accession
P02776
Peptide B accession
P02776
Peptide A residue number
83
Peptide B residue number
83
Ligandability
Cysteine 83 of Platelet factor 4
Cysteine 83 of Platelet factor 4
1plf A 27 C 27
A redox-regulated disulphide may form between two units of Platelet factor 4 at cysteines 27 and 27. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
1plf
Structure name
the three-dimensional structure of bovine platelet factor 4 at 3
Structure deposition date
1993-10-20
Thiol separation (Å)
9
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide A name
Platelet factor 4
Peptide B name
Platelet factor 4
Peptide A accession
P02777
Peptide B accession
P02777
Peptide A residue number
27
Peptide B residue number
27
Ligandability
1f9s B 152 C 212
A redox-regulated disulphide may form between two units of Platelet factor 4 at cysteines 83 and 43 (152 and 212 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
1f9s
Structure name
crystal structure of platelet factor 4 mutant 2
Structure deposition date
2000-07-11
Thiol separation (Å)
9
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide A name
Platelet factor 4
Peptide B name
Platelet factor 4
Peptide A accession
P02776
Peptide B accession
P02776
Peptide A residue number
83
Peptide B residue number
43
Ligandability
Cysteine 83 of Platelet factor 4
Cysteine 43 of Platelet factor 4
1plf A 25 C 67
A redox-regulated disulphide may form between two units of Platelet factor 4 at cysteines 25 and 67. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
35
PDB code
1plf
Structure name
the three-dimensional structure of bovine platelet factor 4 at 3
Structure deposition date
1993-10-20
Thiol separation (Å)
10
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide A name
Platelet factor 4
Peptide B name
Platelet factor 4
Peptide A accession
P02777
Peptide B accession
P02777
Peptide A residue number
25
Peptide B residue number
67
Ligandability
Cysteine 25 of Platelet factor 4
Cysteine 67 of Platelet factor 4
1f9q D 310 D 336
A redox-regulated disulphide may form within Platelet factor 4 between cysteines 41 and 67 (310 and 336 respectively in this structure).
Details
Redox score ?
86
PDB code
1f9q
Structure name
crystal structure of platelet factor 4
Structure deposition date
2000-07-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
P02776
Residue number A
41
Residue number B
67
Peptide name
Platelet factor 4
Ligandability
Cysteine 41 of Platelet factor 4
Cysteine 67 of Platelet factor 4
1f9s C 212 C 236
A redox-regulated disulphide may form within Platelet factor 4 between cysteines 43 and 67 (212 and 236 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
55
PDB code
1f9s
Structure name
crystal structure of platelet factor 4 mutant 2
Structure deposition date
2000-07-11
Thiol separation (Å)
7
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
P02776
Residue number A
43
Residue number B
67
Peptide name
Platelet factor 4
Ligandability
Cysteine 43 of Platelet factor 4
Cysteine 67 of Platelet factor 4
1rhp C 10 C 12
A redox-regulated disulphide may form within Platelet factor 4 between cysteines 41 and 43 (10 and 12 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
1rhp
Structure name
crystal structure of recombinant human platelet factor 4
Structure deposition date
1994-09-16
Thiol separation (Å)
9
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
P02776
Residue number A
41
Residue number B
43
Peptide name
Platelet factor 4
Ligandability
Cysteine 41 of Platelet factor 4
Cysteine 43 of Platelet factor 4
1rhp D 36 D 52
A redox-regulated disulphide may form within Platelet factor 4 between cysteines 67 and 83 (36 and 52 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
1rhp
Structure name
crystal structure of recombinant human platelet factor 4
Structure deposition date
1994-09-16
Thiol separation (Å)
9
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
P02776
Residue number A
67
Residue number B
83
Peptide name
Platelet factor 4
Ligandability
Cysteine 67 of Platelet factor 4
Cysteine 83 of Platelet factor 4
1rhp A 10 A 52
A redox-regulated disulphide may form within Platelet factor 4 between cysteines 41 and 83 (10 and 52 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
1rhp
Structure name
crystal structure of recombinant human platelet factor 4
Structure deposition date
1994-09-16
Thiol separation (Å)
9
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
P02776
Residue number A
41
Residue number B
83
Peptide name
Platelet factor 4
Ligandability
Cysteine 41 of Platelet factor 4
Cysteine 83 of Platelet factor 4
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