ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Transferrin receptor protein 1

Intramolecular
Cysteine 353 and cysteine 363
Cysteine 556 and cysteine 558
A redox-regulated disulphide may form within Transferrin receptor protein 1 between cysteines 353 and 363.

Details

Redox score ?
85
PDB code
3s9n
Structure name
complex between transferrin receptor 1 and transferrin with iron in the n-lobe, room temperature
Structure deposition date
2011-06-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
P02786
Residue number A
353
Residue number B
363
Peptide name
Transferrin receptor protein 1

Ligandability

Cysteine 353 of Transferrin receptor protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 363 of Transferrin receptor protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transferrin receptor protein 1 between cysteines 556 and 558.

Details

Redox score ?
77
PDB code
6wrx
Structure name
crystal structure of computationally designed protein 2ds25
Structure deposition date
2020-04-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
66
Minimum pKa ?
7
% buried
72
Peptide accession
P02786
Residue number A
556
Residue number B
558
Peptide name
Transferrin receptor protein 1

Ligandability

Cysteine 556 of Transferrin receptor protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 558 of Transferrin receptor protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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