a tool for identifying drug-targetable redox-active disulphides

Osteocalcin

Intramolecular

Cysteine 74 and cysteine 80

A redox-regulated disulphide may form within Osteocalcin between cysteines 74 and 80 (23 and 29 respectively in this structure).

Details

Redox score ?

86

PDB code

Structure name

crystal structure of bovine 3 glu-osteocalcin

Structure deposition date

2013-09-30

Thiol separation (Å)

2

Half-sphere exposure sum ?

56

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

74

Residue number B

80

Peptide name

Osteocalcin

Ligandability

Cysteine 74 of Osteocalcin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 80 of Osteocalcin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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