ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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NADH-ubiquinone oxidoreductase chain 4L

Intermolecular
Cysteine 16 of NADH-ubiquinone oxidoreductase chain 6 and cysteine 32
Cysteine 16 of NADH-ubiquinone oxidoreductase chain 6 and cysteine 32
A redox-regulated disulphide may form between cysteine 16 of NADH-ubiquinone oxidoreductase chain 6 and cysteine 32 of NADH-ubiquinone oxidoreductase chain 4L. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
7ak6
Structure name
cryo-em structure of nd6-p25l mutant respiratory complex i from mus musculus at 3
Structure deposition date
2020-09-29
Thiol separation (Å)
8
Half-sphere exposure sum ?
94
Minimum pKa ?
11
% buried
100
Peptide A name
NADH-ubiquinone oxidoreductase chain 6
Peptide B name
NADH-ubiquinone oxidoreductase chain 4L
Peptide A accession
A9UIY5
Peptide B accession
P03903
Peptide A residue number
16
Peptide B residue number
32

Ligandability

Cysteine 16 of NADH-ubiquinone oxidoreductase chain 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 32 of NADH-ubiquinone oxidoreductase chain 4L

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 16 of NADH-ubiquinone oxidoreductase chain 6 and cysteine 32 of NADH-ubiquinone oxidoreductase chain 4L. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
7b93
Structure name
cryo-em structure of mitochondrial complex i from mus musculus inhibited by iacs-2858 at 3
Structure deposition date
2020-12-14
Thiol separation (Å)
9
Half-sphere exposure sum ?
99
Minimum pKa ?
11
% buried
100
Peptide A name
NADH-ubiquinone oxidoreductase chain 6
Peptide B name
NADH-ubiquinone oxidoreductase chain 4L
Peptide A accession
P03925
Peptide B accession
P03903
Peptide A residue number
16
Peptide B residue number
32

Ligandability

Cysteine 16 of NADH-ubiquinone oxidoreductase chain 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 32 of NADH-ubiquinone oxidoreductase chain 4L

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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