ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

NADH-ubiquinone oxidoreductase chain 5

Intramolecular
Cysteine 342 and cysteine 372
A redox-regulated disulphide may form within NADH-ubiquinone oxidoreductase chain 5 between cysteines 342 and 372. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
6g72
Structure name
mouse mitochondrial complex i in the deactive state
Structure deposition date
2018-04-04
Thiol separation (Å)
6
Half-sphere exposure sum ?
101
Minimum pKa ?
12
% buried
100
Peptide accession
P03921
Residue number A
342
Residue number B
372
Peptide name
NADH-ubiquinone oxidoreductase chain 5

Ligandability

Cysteine 342 of NADH-ubiquinone oxidoreductase chain 5

Cysteine 372 of NADH-ubiquinone oxidoreductase chain 5

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