ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Angiogenin

Intramolecular
Cysteine 63 and cysteine 116
Cysteine 81 and cysteine 131
Cysteine 50 and cysteine 105
Cysteine 71 and cysteine 131
Cysteine 131 and cysteine 131
Cysteine 50 and cysteine 116
Cysteine 105 and cysteine 116
Cysteine 81 and cysteine 71
A redox-regulated disulphide may form within Angiogenin between cysteines 63 and 116 (39 and 92 respectively in this structure).

Details

Redox score ?
87
PDB code
4ahk
Structure name
k54e - angiogenin mutants and amyotrophic lateral sclerosis - a biochemical and biological analysis
Structure deposition date
2012-02-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
P03950
Residue number A
63
Residue number B
116
Peptide name
Angiogenin

Ligandability

Cysteine 63 of Angiogenin

Cysteine 116 of Angiogenin

A redox-regulated disulphide may form within Angiogenin between cysteines 81 and 131 (57 and 107 respectively in this structure).

Details

Redox score ?
84
PDB code
4ahh
Structure name
r31k - angiogenin mutants and amyotrophic lateral sclerosis - a biochemical and biological analysis
Structure deposition date
2012-02-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
P03950
Residue number A
81
Residue number B
131
Peptide name
Angiogenin

Ligandability

Cysteine 81 of Angiogenin

Cysteine 131 of Angiogenin

A redox-regulated disulphide may form within Angiogenin between cysteines 50 and 105 (26 and 81 respectively in this structure).

Details

Redox score ?
82
PDB code
8af0
Structure name
crystal structure of human angiogenin and rna duplex
Structure deposition date
2022-07-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
P03950
Residue number A
50
Residue number B
105
Peptide name
Angiogenin

Ligandability

Cysteine 50 of Angiogenin

Cysteine 105 of Angiogenin

A redox-regulated disulphide may form within Angiogenin between cysteines 71 and 131 (71 and 109 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
1gv7
Structure name
arh-i, an angiogenin/rnase a chimera
Structure deposition date
2002-02-06
Thiol separation (Å)
8
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
P03950
Residue number A
71
Residue number B
131
Peptide name
Angiogenin

Ligandability

Cysteine 71 of Angiogenin

Cysteine 131 of Angiogenin

Cysteine 71 in protein A could not be asigned to a Uniprot residue.
A redox-regulated disulphide may form within Angiogenin between cysteines 131 and 131 (64 and 109 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
1gv7
Structure name
arh-i, an angiogenin/rnase a chimera
Structure deposition date
2002-02-06
Thiol separation (Å)
9
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
P03950
Residue number A
131
Residue number B
131
Peptide name
Angiogenin

Ligandability

Cysteine 131 of Angiogenin

Cysteine 131 of Angiogenin

A redox-regulated disulphide may form within Angiogenin between cysteines 50 and 116 (26 and 92 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
1awz
Structure name
3d solution structure of human angiogenin determined by 1h, 15n nmr spectroscopy, 30 structures
Structure deposition date
1997-10-07
Thiol separation (Å)
10
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
P03950
Residue number A
50
Residue number B
116
Peptide name
Angiogenin

Ligandability

Cysteine 50 of Angiogenin

Cysteine 116 of Angiogenin

A redox-regulated disulphide may form within Angiogenin between cysteines 105 and 116 (81 and 92 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
1awz
Structure name
3d solution structure of human angiogenin determined by 1h, 15n nmr spectroscopy, 30 structures
Structure deposition date
1997-10-07
Thiol separation (Å)
10
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
P03950
Residue number A
105
Residue number B
116
Peptide name
Angiogenin

Ligandability

Cysteine 105 of Angiogenin

Cysteine 116 of Angiogenin

A redox-regulated disulphide may form within Angiogenin between cysteines 81 and 71 (57 and 71 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
1gv7
Structure name
arh-i, an angiogenin/rnase a chimera
Structure deposition date
2002-02-06
Thiol separation (Å)
10
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
P03950
Residue number A
81
Residue number B
71
Peptide name
Angiogenin

Ligandability

Cysteine 81 of Angiogenin

Cysteine 71 of Angiogenin

Cysteine 71 in protein B could not be asigned to a Uniprot residue.
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