ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Tissue alpha-L-fucosidase

Intramolecular
Cysteine 271 and cysteine 279
Cysteine 279 and cysteine 296
A redox-regulated disulphide may form within Tissue alpha-L-fucosidase between cysteines 271 and 279 (266 and 274 respectively in this structure).

Details

Redox score ?
84
PDB code
7pls
Structure name
cryo-em structures of human fucosidase fuca1 reveal insight into substate recognition and catalysis
Structure deposition date
2021-09-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
P04066
Residue number A
271
Residue number B
279
Peptide name
Tissue alpha-L-fucosidase

Ligandability

Cysteine 271 of Tissue alpha-L-fucosidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 279 of Tissue alpha-L-fucosidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tissue alpha-L-fucosidase between cysteines 279 and 296 (274 and 291 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
31
PDB code
7pls
Structure name
cryo-em structures of human fucosidase fuca1 reveal insight into substate recognition and catalysis
Structure deposition date
2021-09-01
Thiol separation (Å)
9
Half-sphere exposure sum ?
69
Minimum pKa ?
13
% buried
nan
Peptide accession
P04066
Residue number A
279
Residue number B
296
Peptide name
Tissue alpha-L-fucosidase

Ligandability

Cysteine 279 of Tissue alpha-L-fucosidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 296 of Tissue alpha-L-fucosidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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