Vitamin K-dependent protein C
Intermolecular
Cysteine 319 and cysteine 183
Intramolecular
Cysteine 92 and cysteine 111
Cysteine 59 and cysteine 64
Cysteine 105 and cysteine 120
Cysteine 122 and cysteine 131
Cysteine 147 and cysteine 160
Cysteine 162 and cysteine 175
Cysteine 101 and cysteine 106
Cysteine 140 and cysteine 151
Cysteine 398 and cysteine 426
More...Cysteine 373 and cysteine 387
Cysteine 238 and cysteine 254
Cysteine 120 and cysteine 131
Cysteine 105 and cysteine 111
Cysteine 147 and cysteine 151
Cysteine 105 and cysteine 131
Cysteine 111 and cysteine 120
Cysteine 140 and cysteine 147
Cysteine 151 and cysteine 160
Cysteine 120 and cysteine 122
Cysteine 92 and cysteine 120
Cysteine 92 and cysteine 105
Cysteine 105 and cysteine 122
Cysteine 140 and cysteine 160
Cysteine 106 and cysteine 131
Cysteine 106 and cysteine 120
Cysteine 160 and cysteine 175
Cysteine 92 and cysteine 131
Cysteine 147 and cysteine 175
Cysteine 160 and cysteine 162
Cysteine 105 and cysteine 106
Cysteine 111 and cysteine 131
Cysteine 101 and cysteine 120
Cysteine 101 and cysteine 131
Cysteine 106 and cysteine 122
Cysteine 101 and cysteine 105
Cysteine 147 and cysteine 162
Cysteine 92 and cysteine 122
Cysteine 111 and cysteine 122
Cysteine 92 and cysteine 106
6m3c G 319 I 183
A redox-regulated disulphide may form between two units of Vitamin K-dependent protein C at cysteines 319 and 183.
Details
Redox score ?
78
PDB code
6m3c
Structure name
hapc-h1573 fab complex
Structure deposition date
2020-03-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
86
Minimum pKa ?
nan
% buried
nan
Peptide A name
Vitamin K-dependent protein C
Peptide B name
Vitamin K-dependent protein C
Peptide A accession
P04070
Peptide B accession
P04070
Peptide A residue number
319
Peptide B residue number
183
Ligandability
Cysteine 319 of Vitamin K-dependent protein C
Cysteine 183 of Vitamin K-dependent protein C
6m3b D 50 D 69
A redox-regulated disulphide may form within Vitamin K-dependent protein C between cysteines 92 and 111 (50 and 69 respectively in this structure).
Details
Redox score ?
92
PDB code
6m3b
Structure name
hapc-c25k23 fab complex
Structure deposition date
2020-03-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P04070
Residue number A
92
Residue number B
111
Peptide name
Vitamin K-dependent protein C
Ligandability
Cysteine 92 of Vitamin K-dependent protein C
Cysteine 111 of Vitamin K-dependent protein C
3jtc D 17 D 22
A redox-regulated disulphide may form within Vitamin K-dependent protein C between cysteines 59 and 64 (17 and 22 respectively in this structure).
Details
Redox score ?
92
PDB code
3jtc
Structure name
importance of mg2+ in the ca2+-dependent folding of the gamma- carboxyglutamic acid domains of vitamin k-dependent clotting and anticlotting proteins
Structure deposition date
2009-09-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P04070
Residue number A
59
Residue number B
64
Peptide name
Vitamin K-dependent protein C
Ligandability
Cysteine 59 of Vitamin K-dependent protein C
Cysteine 64 of Vitamin K-dependent protein C
1aut L 63 L 78
A redox-regulated disulphide may form within Vitamin K-dependent protein C between cysteines 105 and 120 (63 and 78 respectively in this structure).
Details
Redox score ?
88
PDB code
1aut
Structure name
human activated protein c
Structure deposition date
1996-06-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
P04070
Residue number A
105
Residue number B
120
Peptide name
Vitamin K-dependent protein C
Ligandability
Cysteine 105 of Vitamin K-dependent protein C
Cysteine 120 of Vitamin K-dependent protein C
1aut L 80 L 89
A redox-regulated disulphide may form within Vitamin K-dependent protein C between cysteines 122 and 131 (80 and 89 respectively in this structure).
Details
Redox score ?
87
PDB code
1aut
Structure name
human activated protein c
Structure deposition date
1996-06-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
P04070
Residue number A
122
Residue number B
131
Peptide name
Vitamin K-dependent protein C
Ligandability
Cysteine 122 of Vitamin K-dependent protein C
Cysteine 131 of Vitamin K-dependent protein C
1aut L 105 L 118
A redox-regulated disulphide may form within Vitamin K-dependent protein C between cysteines 147 and 160 (105 and 118 respectively in this structure).
Details
Redox score ?
86
PDB code
1aut
Structure name
human activated protein c
Structure deposition date
1996-06-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
P04070
Residue number A
147
Residue number B
160
Peptide name
Vitamin K-dependent protein C
Ligandability
Cysteine 147 of Vitamin K-dependent protein C
Cysteine 160 of Vitamin K-dependent protein C
6m3c B 162 B 175
A redox-regulated disulphide may form within Vitamin K-dependent protein C between cysteines 162 and 175.
Details
Redox score ?
86
PDB code
6m3c
Structure name
hapc-h1573 fab complex
Structure deposition date
2020-03-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
P04070
Residue number A
162
Residue number B
175
Peptide name
Vitamin K-dependent protein C
Ligandability
Cysteine 162 of Vitamin K-dependent protein C
Cysteine 175 of Vitamin K-dependent protein C
3f6u L 59 L 64
A redox-regulated disulphide may form within Vitamin K-dependent protein C between cysteines 101 and 106 (59 and 64 respectively in this structure).
Details
Redox score ?
85
PDB code
3f6u
Structure name
crystal structure of human activated protein c (apc) complexed with ppack
Structure deposition date
2008-11-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
44
Minimum pKa ?
nan
% buried
nan
Peptide accession
P04070
Residue number A
101
Residue number B
106
Peptide name
Vitamin K-dependent protein C
Ligandability
Cysteine 101 of Vitamin K-dependent protein C
Cysteine 106 of Vitamin K-dependent protein C
1aut L 98 L 109
A redox-regulated disulphide may form within Vitamin K-dependent protein C between cysteines 140 and 151 (98 and 109 respectively in this structure).
Details
Redox score ?
83
PDB code
1aut
Structure name
human activated protein c
Structure deposition date
1996-06-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
P04070
Residue number A
140
Residue number B
151
Peptide name
Vitamin K-dependent protein C
Ligandability
Cysteine 140 of Vitamin K-dependent protein C
Cysteine 151 of Vitamin K-dependent protein C
3f6u H 191 H 220
A redox-regulated disulphide may form within Vitamin K-dependent protein C between cysteines 398 and 426 (191 and 220 respectively in this structure).
Details
Redox score ?
82
PDB code
3f6u
Structure name
crystal structure of human activated protein c (apc) complexed with ppack
Structure deposition date
2008-11-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
P04070
Residue number A
398
Residue number B
426
Peptide name
Vitamin K-dependent protein C
Ligandability
Cysteine 398 of Vitamin K-dependent protein C
Cysteine 426 of Vitamin K-dependent protein C
6m3c C 373 C 387
A redox-regulated disulphide may form within Vitamin K-dependent protein C between cysteines 373 and 387.
Details
Redox score ?
81
PDB code
6m3c
Structure name
hapc-h1573 fab complex
Structure deposition date
2020-03-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
P04070
Residue number A
373
Residue number B
387
Peptide name
Vitamin K-dependent protein C
Ligandability
Cysteine 373 of Vitamin K-dependent protein C
Cysteine 387 of Vitamin K-dependent protein C
3f6u H 42 H 58
A redox-regulated disulphide may form within Vitamin K-dependent protein C between cysteines 238 and 254 (42 and 58 respectively in this structure).
Details
Redox score ?
80
PDB code
3f6u
Structure name
crystal structure of human activated protein c (apc) complexed with ppack
Structure deposition date
2008-11-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
87
Minimum pKa ?
nan
% buried
nan
Peptide accession
P04070
Residue number A
238
Residue number B
254
Peptide name
Vitamin K-dependent protein C
Ligandability
Cysteine 238 of Vitamin K-dependent protein C
Cysteine 254 of Vitamin K-dependent protein C
3f6u L 78 L 89
A redox-regulated disulphide may form within Vitamin K-dependent protein C between cysteines 120 and 131 (78 and 89 respectively in this structure).
Details
Redox score ?
74
PDB code
3f6u
Structure name
crystal structure of human activated protein c (apc) complexed with ppack
Structure deposition date
2008-11-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
P04070
Residue number A
120
Residue number B
131
Peptide name
Vitamin K-dependent protein C
Ligandability
Cysteine 120 of Vitamin K-dependent protein C
Cysteine 131 of Vitamin K-dependent protein C
3f6u L 63 L 69
A redox-regulated disulphide may form within Vitamin K-dependent protein C between cysteines 105 and 111 (63 and 69 respectively in this structure).
Details
Redox score ?
73
PDB code
3f6u
Structure name
crystal structure of human activated protein c (apc) complexed with ppack
Structure deposition date
2008-11-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
P04070
Residue number A
105
Residue number B
111
Peptide name
Vitamin K-dependent protein C
Ligandability
Cysteine 105 of Vitamin K-dependent protein C
Cysteine 111 of Vitamin K-dependent protein C
6m3b D 105 D 109
A redox-regulated disulphide may form within Vitamin K-dependent protein C between cysteines 147 and 151 (105 and 109 respectively in this structure).
Details
Redox score ?
73
PDB code
6m3b
Structure name
hapc-c25k23 fab complex
Structure deposition date
2020-03-03
Thiol separation (Å)
4
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
P04070
Residue number A
147
Residue number B
151
Peptide name
Vitamin K-dependent protein C
Ligandability
Cysteine 147 of Vitamin K-dependent protein C
Cysteine 151 of Vitamin K-dependent protein C
1aut L 63 L 89
A redox-regulated disulphide may form within Vitamin K-dependent protein C between cysteines 105 and 131 (63 and 89 respectively in this structure).
Details
Redox score ?
71
PDB code
1aut
Structure name
human activated protein c
Structure deposition date
1996-06-08
Thiol separation (Å)
4
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
P04070
Residue number A
105
Residue number B
131
Peptide name
Vitamin K-dependent protein C
Ligandability
Cysteine 105 of Vitamin K-dependent protein C
Cysteine 131 of Vitamin K-dependent protein C
6m3b D 69 D 78
A redox-regulated disulphide may form within Vitamin K-dependent protein C between cysteines 111 and 120 (69 and 78 respectively in this structure).
Details
Redox score ?
71
PDB code
6m3b
Structure name
hapc-c25k23 fab complex
Structure deposition date
2020-03-03
Thiol separation (Å)
5
Half-sphere exposure sum ?
48
Minimum pKa ?
nan
% buried
nan
Peptide accession
P04070
Residue number A
111
Residue number B
120
Peptide name
Vitamin K-dependent protein C
Ligandability
Cysteine 111 of Vitamin K-dependent protein C
Cysteine 120 of Vitamin K-dependent protein C
6m3c I 140 I 147
A redox-regulated disulphide may form within Vitamin K-dependent protein C between cysteines 140 and 147.
Details
Redox score ?
67
PDB code
6m3c
Structure name
hapc-h1573 fab complex
Structure deposition date
2020-03-03
Thiol separation (Å)
6
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
P04070
Residue number A
140
Residue number B
147
Peptide name
Vitamin K-dependent protein C
Ligandability
Cysteine 140 of Vitamin K-dependent protein C
Cysteine 147 of Vitamin K-dependent protein C
6m3c D 151 D 160
A redox-regulated disulphide may form within Vitamin K-dependent protein C between cysteines 151 and 160.
Details
Redox score ?
66
PDB code
6m3c
Structure name
hapc-h1573 fab complex
Structure deposition date
2020-03-03
Thiol separation (Å)
5
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
P04070
Residue number A
151
Residue number B
160
Peptide name
Vitamin K-dependent protein C
Ligandability
Cysteine 151 of Vitamin K-dependent protein C
Cysteine 160 of Vitamin K-dependent protein C
6m3b D 78 D 80
A redox-regulated disulphide may form within Vitamin K-dependent protein C between cysteines 120 and 122 (78 and 80 respectively in this structure).
Details
Redox score ?
65
PDB code
6m3b
Structure name
hapc-c25k23 fab complex
Structure deposition date
2020-03-03
Thiol separation (Å)
6
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide accession
P04070
Residue number A
120
Residue number B
122
Peptide name
Vitamin K-dependent protein C
Ligandability
Cysteine 120 of Vitamin K-dependent protein C
Cysteine 122 of Vitamin K-dependent protein C
6m3b D 50 D 78
A redox-regulated disulphide may form within Vitamin K-dependent protein C between cysteines 92 and 120 (50 and 78 respectively in this structure).
Details
Redox score ?
63
PDB code
6m3b
Structure name
hapc-c25k23 fab complex
Structure deposition date
2020-03-03
Thiol separation (Å)
7
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P04070
Residue number A
92
Residue number B
120
Peptide name
Vitamin K-dependent protein C
Ligandability
Cysteine 92 of Vitamin K-dependent protein C
Cysteine 120 of Vitamin K-dependent protein C
6m3b D 50 D 63
A redox-regulated disulphide may form within Vitamin K-dependent protein C between cysteines 92 and 105 (50 and 63 respectively in this structure).
Details
Redox score ?
62
PDB code
6m3b
Structure name
hapc-c25k23 fab complex
Structure deposition date
2020-03-03
Thiol separation (Å)
7
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P04070
Residue number A
92
Residue number B
105
Peptide name
Vitamin K-dependent protein C
Ligandability
Cysteine 92 of Vitamin K-dependent protein C
Cysteine 105 of Vitamin K-dependent protein C
6m3b D 63 D 80
A redox-regulated disulphide may form within Vitamin K-dependent protein C between cysteines 105 and 122 (63 and 80 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
59
PDB code
6m3b
Structure name
hapc-c25k23 fab complex
Structure deposition date
2020-03-03
Thiol separation (Å)
7
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
P04070
Residue number A
105
Residue number B
122
Peptide name
Vitamin K-dependent protein C
Ligandability
Cysteine 105 of Vitamin K-dependent protein C
Cysteine 122 of Vitamin K-dependent protein C
6m3c I 140 I 160
A redox-regulated disulphide may form within Vitamin K-dependent protein C between cysteines 140 and 160. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
57
PDB code
6m3c
Structure name
hapc-h1573 fab complex
Structure deposition date
2020-03-03
Thiol separation (Å)
7
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
P04070
Residue number A
140
Residue number B
160
Peptide name
Vitamin K-dependent protein C
Ligandability
Cysteine 140 of Vitamin K-dependent protein C
Cysteine 160 of Vitamin K-dependent protein C
3f6u L 64 L 89
A redox-regulated disulphide may form within Vitamin K-dependent protein C between cysteines 106 and 131 (64 and 89 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
56
PDB code
3f6u
Structure name
crystal structure of human activated protein c (apc) complexed with ppack
Structure deposition date
2008-11-06
Thiol separation (Å)
7
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
P04070
Residue number A
106
Residue number B
131
Peptide name
Vitamin K-dependent protein C
Ligandability
Cysteine 106 of Vitamin K-dependent protein C
Cysteine 131 of Vitamin K-dependent protein C
6m3b D 64 D 78
A redox-regulated disulphide may form within Vitamin K-dependent protein C between cysteines 106 and 120 (64 and 78 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
55
PDB code
6m3b
Structure name
hapc-c25k23 fab complex
Structure deposition date
2020-03-03
Thiol separation (Å)
7
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide accession
P04070
Residue number A
106
Residue number B
120
Peptide name
Vitamin K-dependent protein C
Ligandability
Cysteine 106 of Vitamin K-dependent protein C
Cysteine 120 of Vitamin K-dependent protein C
6m3c I 160 I 175
A redox-regulated disulphide may form within Vitamin K-dependent protein C between cysteines 160 and 175. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
54
PDB code
6m3c
Structure name
hapc-h1573 fab complex
Structure deposition date
2020-03-03
Thiol separation (Å)
7
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
P04070
Residue number A
160
Residue number B
175
Peptide name
Vitamin K-dependent protein C
Ligandability
Cysteine 160 of Vitamin K-dependent protein C
Cysteine 175 of Vitamin K-dependent protein C
1aut L 50 L 89
A redox-regulated disulphide may form within Vitamin K-dependent protein C between cysteines 92 and 131 (50 and 89 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
54
PDB code
1aut
Structure name
human activated protein c
Structure deposition date
1996-06-08
Thiol separation (Å)
8
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
P04070
Residue number A
92
Residue number B
131
Peptide name
Vitamin K-dependent protein C
Ligandability
Cysteine 92 of Vitamin K-dependent protein C
Cysteine 131 of Vitamin K-dependent protein C
1aut L 105 L 133
A redox-regulated disulphide may form within Vitamin K-dependent protein C between cysteines 147 and 175 (105 and 133 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
53
PDB code
1aut
Structure name
human activated protein c
Structure deposition date
1996-06-08
Thiol separation (Å)
8
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
P04070
Residue number A
147
Residue number B
175
Peptide name
Vitamin K-dependent protein C
Ligandability
Cysteine 147 of Vitamin K-dependent protein C
Cysteine 175 of Vitamin K-dependent protein C
6m3b D 118 D 120
A redox-regulated disulphide may form within Vitamin K-dependent protein C between cysteines 160 and 162 (118 and 120 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
52
PDB code
6m3b
Structure name
hapc-c25k23 fab complex
Structure deposition date
2020-03-03
Thiol separation (Å)
8
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
P04070
Residue number A
160
Residue number B
162
Peptide name
Vitamin K-dependent protein C
Ligandability
Cysteine 160 of Vitamin K-dependent protein C
Cysteine 162 of Vitamin K-dependent protein C
3f6u L 63 L 64
A redox-regulated disulphide may form within Vitamin K-dependent protein C between cysteines 105 and 106 (63 and 64 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
51
PDB code
3f6u
Structure name
crystal structure of human activated protein c (apc) complexed with ppack
Structure deposition date
2008-11-06
Thiol separation (Å)
8
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
P04070
Residue number A
105
Residue number B
106
Peptide name
Vitamin K-dependent protein C
Ligandability
Cysteine 105 of Vitamin K-dependent protein C
Cysteine 106 of Vitamin K-dependent protein C
3f6u L 69 L 89
A redox-regulated disulphide may form within Vitamin K-dependent protein C between cysteines 111 and 131 (69 and 89 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
50
PDB code
3f6u
Structure name
crystal structure of human activated protein c (apc) complexed with ppack
Structure deposition date
2008-11-06
Thiol separation (Å)
8
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
P04070
Residue number A
111
Residue number B
131
Peptide name
Vitamin K-dependent protein C
Ligandability
Cysteine 111 of Vitamin K-dependent protein C
Cysteine 131 of Vitamin K-dependent protein C
1aut L 59 L 78
A redox-regulated disulphide may form within Vitamin K-dependent protein C between cysteines 101 and 120 (59 and 78 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
49
PDB code
1aut
Structure name
human activated protein c
Structure deposition date
1996-06-08
Thiol separation (Å)
9
Half-sphere exposure sum ?
43
Minimum pKa ?
nan
% buried
nan
Peptide accession
P04070
Residue number A
101
Residue number B
120
Peptide name
Vitamin K-dependent protein C
Ligandability
Cysteine 101 of Vitamin K-dependent protein C
Cysteine 120 of Vitamin K-dependent protein C
3f6u L 59 L 89
A redox-regulated disulphide may form within Vitamin K-dependent protein C between cysteines 101 and 131 (59 and 89 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
49
PDB code
3f6u
Structure name
crystal structure of human activated protein c (apc) complexed with ppack
Structure deposition date
2008-11-06
Thiol separation (Å)
9
Half-sphere exposure sum ?
45
Minimum pKa ?
nan
% buried
nan
Peptide accession
P04070
Residue number A
101
Residue number B
131
Peptide name
Vitamin K-dependent protein C
Ligandability
Cysteine 101 of Vitamin K-dependent protein C
Cysteine 131 of Vitamin K-dependent protein C
3f6u L 64 L 80
A redox-regulated disulphide may form within Vitamin K-dependent protein C between cysteines 106 and 122 (64 and 80 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
3f6u
Structure name
crystal structure of human activated protein c (apc) complexed with ppack
Structure deposition date
2008-11-06
Thiol separation (Å)
8
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
P04070
Residue number A
106
Residue number B
122
Peptide name
Vitamin K-dependent protein C
Ligandability
Cysteine 106 of Vitamin K-dependent protein C
Cysteine 122 of Vitamin K-dependent protein C
3f6u L 59 L 63
A redox-regulated disulphide may form within Vitamin K-dependent protein C between cysteines 101 and 105 (59 and 63 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
3f6u
Structure name
crystal structure of human activated protein c (apc) complexed with ppack
Structure deposition date
2008-11-06
Thiol separation (Å)
9
Half-sphere exposure sum ?
48
Minimum pKa ?
nan
% buried
nan
Peptide accession
P04070
Residue number A
101
Residue number B
105
Peptide name
Vitamin K-dependent protein C
Ligandability
Cysteine 101 of Vitamin K-dependent protein C
Cysteine 105 of Vitamin K-dependent protein C
6m3b D 105 D 120
A redox-regulated disulphide may form within Vitamin K-dependent protein C between cysteines 147 and 162 (105 and 120 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
6m3b
Structure name
hapc-c25k23 fab complex
Structure deposition date
2020-03-03
Thiol separation (Å)
9
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
P04070
Residue number A
147
Residue number B
162
Peptide name
Vitamin K-dependent protein C
Ligandability
Cysteine 147 of Vitamin K-dependent protein C
Cysteine 162 of Vitamin K-dependent protein C
3f6u L 50 L 80
A redox-regulated disulphide may form within Vitamin K-dependent protein C between cysteines 92 and 122 (50 and 80 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
3f6u
Structure name
crystal structure of human activated protein c (apc) complexed with ppack
Structure deposition date
2008-11-06
Thiol separation (Å)
10
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide accession
P04070
Residue number A
92
Residue number B
122
Peptide name
Vitamin K-dependent protein C
Ligandability
Cysteine 92 of Vitamin K-dependent protein C
Cysteine 122 of Vitamin K-dependent protein C
1aut L 69 L 80
A redox-regulated disulphide may form within Vitamin K-dependent protein C between cysteines 111 and 122 (69 and 80 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
1aut
Structure name
human activated protein c
Structure deposition date
1996-06-08
Thiol separation (Å)
10
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide accession
P04070
Residue number A
111
Residue number B
122
Peptide name
Vitamin K-dependent protein C
Ligandability
Cysteine 111 of Vitamin K-dependent protein C
Cysteine 122 of Vitamin K-dependent protein C
1aut L 50 L 64
A redox-regulated disulphide may form within Vitamin K-dependent protein C between cysteines 92 and 106 (50 and 64 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
1aut
Structure name
human activated protein c
Structure deposition date
1996-06-08
Thiol separation (Å)
10
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide accession
P04070
Residue number A
92
Residue number B
106
Peptide name
Vitamin K-dependent protein C
Ligandability
Cysteine 92 of Vitamin K-dependent protein C
Cysteine 106 of Vitamin K-dependent protein C
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