ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Granulocyte-macrophage colony-stimulating factor

Intramolecular
Cysteine 105 and cysteine 138
Cysteine 71 and cysteine 113
A redox-regulated disulphide may form within Granulocyte-macrophage colony-stimulating factor between cysteines 105 and 138 (88 and 121 respectively in this structure).

Details

Redox score ?
87
PDB code
2gmf
Structure name
human granulocyte macrophage colony stimulating factor
Structure deposition date
1996-04-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
P04141
Residue number A
105
Residue number B
138
Peptide name
Granulocyte-macrophage colony-stimulating factor

Ligandability

Cysteine 105 of Granulocyte-macrophage colony-stimulating factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 138 of Granulocyte-macrophage colony-stimulating factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Granulocyte-macrophage colony-stimulating factor between cysteines 71 and 113 (54 and 96 respectively in this structure).

Details

Redox score ?
86
PDB code
2gmf
Structure name
human granulocyte macrophage colony stimulating factor
Structure deposition date
1996-04-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
P04141
Residue number A
71
Residue number B
113
Peptide name
Granulocyte-macrophage colony-stimulating factor

Ligandability

Cysteine 71 of Granulocyte-macrophage colony-stimulating factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 113 of Granulocyte-macrophage colony-stimulating factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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