Glucocorticoid receptor

Peptide B accession

Peptide A residue number

457

Peptide B residue number

457

Ligandability

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form between two units of Glucocorticoid receptor at cysteines 473 and 473. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

6x6d

Structure name

glucocorticoid receptor dna binding domain in complex with unmodified precursor for a modern recognition element (pre-gbs)

Structure deposition date

2020-05-28

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide A name

Glucocorticoid receptor

Peptide B name

Glucocorticoid receptor

Peptide A accession

Peptide B accession

Peptide A residue number

473

Peptide B residue number

473

Ligandability

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form between two units of Glucocorticoid receptor at cysteines 622 and 622. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

1m2z

Structure name

crystal structure of a dimer complex of the human glucocorticoid receptor ligand-binding domain bound to dexamethasone and a tif2 coactivator motif

Structure deposition date

2002-06-26

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

100

Peptide A name

Glucocorticoid receptor

Peptide B name

Glucocorticoid receptor

Peptide A accession

Peptide B accession

Peptide A residue number

622

Peptide B residue number

622

Ligandability

Ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Glucocorticoid receptor between cysteines 476 and 495.

Details

Redox score ?

PDB code

1r4r

Structure name

crystallographic analysis of the interaction of the glucocorticoid receptor with dna

Structure deposition date

2003-10-07

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

Residue number A

476

Residue number B

495

Peptide name

Glucocorticoid receptor

Ligandability

Cysteine 476 of Glucocorticoid receptor

Not ligandable in the dataset of Vinogradova et al.

Cysteine 495 of Glucocorticoid receptor

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Glucocorticoid receptor between cysteines 424 and 438.

Details

Redox score ?

PDB code

5e6d

Structure name

glucocorticoid receptor dna binding domain - icam1 nf-kb response element complex

Structure deposition date

2015-10-09

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

Residue number A

424

Residue number B

438

Peptide name

Glucocorticoid receptor

Ligandability

Cysteine 424 of Glucocorticoid receptor

Not ligandable in the dataset of Vinogradova et al.

Cysteine 438 of Glucocorticoid receptor

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Glucocorticoid receptor between cysteines 457 and 460.

Details

Redox score ?

PDB code

3g8x

Structure name

gr dna binding domain:gilz 16bp complex-65

Structure deposition date

2009-02-12

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

Residue number A

457

Residue number B

460

Peptide name

Glucocorticoid receptor

Ligandability

Cysteine 457 of Glucocorticoid receptor

Not ligandable in the dataset of Vinogradova et al.

Cysteine 460 of Glucocorticoid receptor

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Glucocorticoid receptor between cysteines 421 and 438.

Details

Redox score ?

PDB code

5e69

Structure name

glucocorticoid receptor dna binding domain - il8 nf-kb response element complex

Structure deposition date

2015-10-09

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

nan

Peptide accession

Residue number A

421

Residue number B

438

Peptide name

Glucocorticoid receptor

Ligandability

Cysteine 421 of Glucocorticoid receptor

Not ligandable in the dataset of Vinogradova et al.

Cysteine 438 of Glucocorticoid receptor

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Glucocorticoid receptor between cysteines 457 and 463.

Details

Redox score ?

PDB code

5e6d

Structure name

glucocorticoid receptor dna binding domain - icam1 nf-kb response element complex

Structure deposition date

2015-10-09

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

Residue number A

457

Residue number B

463

Peptide name

Glucocorticoid receptor

Ligandability

Cysteine 457 of Glucocorticoid receptor

Not ligandable in the dataset of Vinogradova et al.

Cysteine 463 of Glucocorticoid receptor

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Glucocorticoid receptor between cysteines 492 and 495.

Details

Redox score ?

PDB code

1r4r

Structure name

crystallographic analysis of the interaction of the glucocorticoid receptor with dna

Structure deposition date

2003-10-07

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

Residue number A

492

Residue number B

495

Peptide name

Glucocorticoid receptor

Ligandability

Cysteine 492 of Glucocorticoid receptor

Not ligandable in the dataset of Vinogradova et al.

Cysteine 495 of Glucocorticoid receptor

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Glucocorticoid receptor between cysteines 457 and 473.

Details

Redox score ?

PDB code

7prv

Structure name

the glucocorticoid receptor in complex with fluticasone furoate, a pgc1a coactivator fragment and sgk 23bp

Structure deposition date

2021-09-22

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

nan

Peptide accession

Residue number A

457

Residue number B

473

Peptide name

Glucocorticoid receptor

Ligandability

Cysteine 457 of Glucocorticoid receptor

Not ligandable in the dataset of Vinogradova et al.

Cysteine 473 of Glucocorticoid receptor

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Glucocorticoid receptor between cysteines 463 and 476.

Details

Redox score ?

PDB code

6cfn

Structure name

crystal structure of the dna-free glucocorticoid receptor dna binding domain

Structure deposition date

2018-02-15

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

Residue number A

463

Residue number B

476

Peptide name

Glucocorticoid receptor

Ligandability

Cysteine 463 of Glucocorticoid receptor

Not ligandable in the dataset of Vinogradova et al.

Cysteine 476 of Glucocorticoid receptor

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Glucocorticoid receptor between cysteines 421 and 424.

Details

Redox score ?

PDB code

7prw

Structure name

the glucocorticoid receptor in complex with velsecorat, a pgc1a coactivator fragment and sgk 23bp

Structure deposition date

2021-09-22

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

nan

Peptide accession

Residue number A

421

Residue number B

424

Peptide name

Glucocorticoid receptor

Ligandability

Cysteine 421 of Glucocorticoid receptor

Not ligandable in the dataset of Vinogradova et al.

Cysteine 424 of Glucocorticoid receptor

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Glucocorticoid receptor between cysteines 421 and 441.

Details

Redox score ?

PDB code

5cc1

Structure name

s425g glucocorticoid receptor dna binding domain - (+)gre complex

Structure deposition date

2015-07-01

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

nan

Peptide accession

Residue number A

421

Residue number B

441

Peptide name

Glucocorticoid receptor

Ligandability

Cysteine 421 of Glucocorticoid receptor

Not ligandable in the dataset of Vinogradova et al.

Cysteine 441 of Glucocorticoid receptor

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Glucocorticoid receptor between cysteines 463 and 473.

Details

Redox score ?

PDB code

7prw

Structure name

the glucocorticoid receptor in complex with velsecorat, a pgc1a coactivator fragment and sgk 23bp

Structure deposition date

2021-09-22

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

Residue number A

463

Residue number B

473

Peptide name

Glucocorticoid receptor

Ligandability

Cysteine 463 of Glucocorticoid receptor

Not ligandable in the dataset of Vinogradova et al.

Cysteine 473 of Glucocorticoid receptor

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Glucocorticoid receptor between cysteines 441 and 481.

Details

Redox score ?

PDB code

6x6e

Structure name

glucocorticoid receptor dna binding domain in complex with methylated precursor for a modern recognition element (methylated pre-gbs)

Structure deposition date

2020-05-28

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

Residue number A

441

Residue number B

481

Peptide name

Glucocorticoid receptor

Ligandability

Cysteine 441 of Glucocorticoid receptor

Not ligandable in the dataset of Vinogradova et al.

Cysteine 481 of Glucocorticoid receptor

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Glucocorticoid receptor between cysteines 438 and 481. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

6bse

Structure name

glucocorticoid receptor bound to high cooperativity monomer sequence

Structure deposition date

2017-12-02

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

P79269

Residue number A

438

Residue number B

481

Peptide name

Glucocorticoid receptor

Ligandability

Cysteine 438 of Glucocorticoid receptor

Not ligandable in the dataset of Vinogradova et al.

Cysteine 481 of Glucocorticoid receptor

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Glucocorticoid receptor between cysteines 450 and 457 (11 and 18 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

Structure name

structure refinement of the glucocorticoid receptor-dna binding domain from nmr data by relaxation matrix calculations

Structure deposition date

1995-01-06

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

Residue number A

450

Residue number B

457

Peptide name

Glucocorticoid receptor

Ligandability

Cysteine 450 of Glucocorticoid receptor

Not ligandable in the dataset of Vinogradova et al.

Cysteine 457 of Glucocorticoid receptor

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Glucocorticoid receptor between cysteines 450 and 460 (11 and 21 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

Structure name

structure refinement of the glucocorticoid receptor-dna binding domain from nmr data by relaxation matrix calculations

Structure deposition date

1995-01-06

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

Residue number A

450

Residue number B

460

Peptide name

Glucocorticoid receptor

Ligandability

Cysteine 450 of Glucocorticoid receptor

Not ligandable in the dataset of Vinogradova et al.

Cysteine 460 of Glucocorticoid receptor

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Glucocorticoid receptor between cysteines 421 and 481. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

4hn5

Structure name

gr dna binding domain - tslp ngre complex

Structure deposition date

2012-10-18

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

nan

Peptide accession

Residue number A

421

Residue number B

481

Peptide name

Glucocorticoid receptor

Ligandability

Cysteine 421 of Glucocorticoid receptor

Not ligandable in the dataset of Vinogradova et al.

Cysteine 481 of Glucocorticoid receptor

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Glucocorticoid receptor between cysteines 440 and 450 (1 and 11 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

Structure name

structure refinement of the glucocorticoid receptor-dna binding domain from nmr data by relaxation matrix calculations

Structure deposition date

1995-01-06

Thiol separation (Å)

Half-sphere exposure sum ?

nan

Minimum pK_a ?

% buried

nan

Peptide accession

Residue number A

440

Residue number B

450

Peptide name

Glucocorticoid receptor

Ligandability

Cysteine 440 of Glucocorticoid receptor

Not ligandable in the dataset of Vinogradova et al.

Cysteine 450 of Glucocorticoid receptor

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Glucocorticoid receptor between cysteines 443 and 482 (4 and 43 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

Structure name

structure refinement of the glucocorticoid receptor-dna binding domain from nmr data by relaxation matrix calculations

Structure deposition date

1995-01-06

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

Residue number A

443

Residue number B

482

Peptide name

Glucocorticoid receptor

Ligandability

Cysteine 443 of Glucocorticoid receptor

Not ligandable in the dataset of Vinogradova et al.

Cysteine 482 of Glucocorticoid receptor

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Glucocorticoid receptor between cysteines 424 and 441. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

7prv

Structure name

the glucocorticoid receptor in complex with fluticasone furoate, a pgc1a coactivator fragment and sgk 23bp

Structure deposition date

2021-09-22

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

nan

Peptide accession

Residue number A

424

Residue number B

441

Peptide name

Glucocorticoid receptor

Ligandability

Cysteine 424 of Glucocorticoid receptor

Not ligandable in the dataset of Vinogradova et al.

Cysteine 441 of Glucocorticoid receptor

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Glucocorticoid receptor between cysteines 443 and 495 (4 and 56 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

Structure name

structure refinement of the glucocorticoid receptor-dna binding domain from nmr data by relaxation matrix calculations

Structure deposition date

1995-01-06

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

Residue number A

443

Residue number B

495

Peptide name

Glucocorticoid receptor

Ligandability

Cysteine 443 of Glucocorticoid receptor

Not ligandable in the dataset of Vinogradova et al.

Cysteine 495 of Glucocorticoid receptor

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Glucocorticoid receptor between cysteines 638 and 643. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

7kw7

Structure name

atomic cryoem structure of hsp90-hsp70-hop-gr

Structure deposition date

2020-11-30

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

Residue number A

638

Residue number B

643

Peptide name

Glucocorticoid receptor

Ligandability

Cysteine 638 of Glucocorticoid receptor

Not ligandable in the dataset of Vinogradova et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 643 of Glucocorticoid receptor

Not ligandable in the dataset of Vinogradova et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Glucocorticoid receptor between cysteines 440 and 495 (1 and 56 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

Structure name

structure refinement of the glucocorticoid receptor-dna binding domain from nmr data by relaxation matrix calculations

Structure deposition date

1995-01-06

Thiol separation (Å)

Half-sphere exposure sum ?

nan

Minimum pK_a ?

% buried

nan

Peptide accession

Residue number A

440

Residue number B

495

Peptide name

Glucocorticoid receptor

Ligandability

Cysteine 440 of Glucocorticoid receptor

Not ligandable in the dataset of Vinogradova et al.

Cysteine 495 of Glucocorticoid receptor

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Glucocorticoid receptor between cysteines 460 and 495 (21 and 56 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

Structure name

structure refinement of the glucocorticoid receptor-dna binding domain from nmr data by relaxation matrix calculations

Structure deposition date

1995-01-06

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

Residue number A

460

Residue number B

495

Peptide name

Glucocorticoid receptor

Ligandability

Cysteine 460 of Glucocorticoid receptor

Not ligandable in the dataset of Vinogradova et al.

Cysteine 495 of Glucocorticoid receptor

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Glucocorticoid receptor between cysteines 495 and 500 (56 and 61 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

Structure name

structure refinement of the glucocorticoid receptor-dna binding domain from nmr data by relaxation matrix calculations

Structure deposition date

1995-01-06

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

Residue number A

495

Residue number B

500

Peptide name

Glucocorticoid receptor

Ligandability

Cysteine 495 of Glucocorticoid receptor

Not ligandable in the dataset of Vinogradova et al.

Cysteine 500 of Glucocorticoid receptor

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Glucocorticoid receptor between cysteines 424 and 481. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

4hn6

Structure name

gr dna binding domain r460d/d462r - tslp ngre complex

Structure deposition date

2012-10-18

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

Residue number A

424

Residue number B

481

Peptide name

Glucocorticoid receptor

Ligandability

Cysteine 424 of Glucocorticoid receptor

Not ligandable in the dataset of Vinogradova et al.

Cysteine 481 of Glucocorticoid receptor

Not ligandable in the dataset of Vinogradova et al.

A redox-regulated disulphide may form within Glucocorticoid receptor between cysteines 643 and 736. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

4mdd

Structure name

crystal structure of the glucocorticoid receptor bound to a non- steroidal antagonist reveals repositioning and partial disordering of activation function helix 12

Structure deposition date

2013-08-22

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession