Thymidine kinase, cytosolic
Intramolecular
Cysteine 153 and cysteine 188 L
Cysteine 156 and cysteine 185 L
Cysteine 153 and cysteine 156 L
Cysteine 156 and cysteine 188 L
Cysteine 153 and cysteine 185 L
Cysteine 185 and cysteine 188
1xbt B 153 B 188
A redox-regulated disulphide may form within Thymidine kinase, cytosolic between cysteines 153 and 188.
Details
Redox score ?
83
PDB code
1xbt
Structure name
crystal structure of human thymidine kinase 1
Structure deposition date
2004-08-31
Thiol separation (Å)
3
Half-sphere exposure sum ?
59
Minimum pKa ?
6
% buried
30
Peptide accession
P04183
Residue number A
153
Residue number B
188
Peptide name
Thymidine kinase, cytosolic
Ligandability
Cysteine 153 of Thymidine kinase, cytosolic
Cysteine 188 of Thymidine kinase, cytosolic
1xbt C 156 C 185
A redox-regulated disulphide may form within Thymidine kinase, cytosolic between cysteines 156 and 185.
Details
Redox score ?
82
PDB code
1xbt
Structure name
crystal structure of human thymidine kinase 1
Structure deposition date
2004-08-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
56
Minimum pKa ?
6
% buried
30
Peptide accession
P04183
Residue number A
156
Residue number B
185
Peptide name
Thymidine kinase, cytosolic
Ligandability
Cysteine 156 of Thymidine kinase, cytosolic
Cysteine 185 of Thymidine kinase, cytosolic
1xbt D 153 D 156
A redox-regulated disulphide may form within Thymidine kinase, cytosolic between cysteines 153 and 156.
Details
Redox score ?
80
PDB code
1xbt
Structure name
crystal structure of human thymidine kinase 1
Structure deposition date
2004-08-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
54
Minimum pKa ?
6
% buried
30
Peptide accession
P04183
Residue number A
153
Residue number B
156
Peptide name
Thymidine kinase, cytosolic
Ligandability
Cysteine 153 of Thymidine kinase, cytosolic
Cysteine 156 of Thymidine kinase, cytosolic
1w4r C 156 C 188
A redox-regulated disulphide may form within Thymidine kinase, cytosolic between cysteines 156 and 188.
Details
Redox score ?
79
PDB code
1w4r
Structure name
structure of a type ii thymidine kinase with bound dttp
Structure deposition date
2004-07-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
46
Minimum pKa ?
8
% buried
18
Peptide accession
P04183
Residue number A
156
Residue number B
188
Peptide name
Thymidine kinase, cytosolic
Ligandability
Cysteine 156 of Thymidine kinase, cytosolic
Cysteine 188 of Thymidine kinase, cytosolic
2wvj C 153 C 185
A redox-regulated disulphide may form within Thymidine kinase, cytosolic between cysteines 153 and 185.
Details
Redox score ?
78
PDB code
2wvj
Structure name
mutation of thr163 to ser in human thymidine kinase shifts the specificity from thymidine towards the nucleoside analogue azidothymidine
Structure deposition date
2009-10-17
Thiol separation (Å)
4
Half-sphere exposure sum ?
69
Minimum pKa ?
6
% buried
42
Peptide accession
P04183
Residue number A
153
Residue number B
185
Peptide name
Thymidine kinase, cytosolic
Ligandability
Cysteine 153 of Thymidine kinase, cytosolic
Cysteine 185 of Thymidine kinase, cytosolic
1w4r G 185 G 188
A redox-regulated disulphide may form within Thymidine kinase, cytosolic between cysteines 185 and 188.
Details
Redox score ?
73
PDB code
1w4r
Structure name
structure of a type ii thymidine kinase with bound dttp
Structure deposition date
2004-07-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
60
Minimum pKa ?
10
% buried
29
Peptide accession
P04183
Residue number A
185
Residue number B
188
Peptide name
Thymidine kinase, cytosolic
Ligandability
Cysteine 185 of Thymidine kinase, cytosolic
Cysteine 188 of Thymidine kinase, cytosolic
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