a tool for identifying drug-targetable redox-active disulphides

Protein S100-B

Intermolecular

Cysteine 85 and cysteine 85

A redox-regulated disulphide may form between two units of Protein S100-B at cysteines 85 and 85 (84 and 84 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

39

PDB code

Structure name

x-ray structure of human ca2+-loaded s100b

Structure deposition date

2006-05-30

Thiol separation (Å)

8

Half-sphere exposure sum ?

59

Minimum pK_a ?

12

% buried

90

Peptide A name

Protein S100-B

Peptide B name

Protein S100-B

Peptide A accession

Peptide B accession

Peptide A residue number

85

Peptide B residue number

85

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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