ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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HLA class II histocompatibility antigen, DP beta 1 chain

Intramolecular
Cysteine 144 and cysteine 200
Cysteine 44 and cysteine 106
A redox-regulated disulphide may form within HLA class II histocompatibility antigen, DP beta 1 chain between cysteines 144 and 200 (117 and 173 respectively in this structure).

Details

Redox score ?
81
PDB code
7t2b
Structure name
crystal structure of the 5f tcr in complex with hla-dp4-ply
Structure deposition date
2021-12-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
P04440
Residue number A
144
Residue number B
200
Peptide name
HLA class II histocompatibility antigen, DP beta 1 chain

Ligandability

Cysteine 144 of HLA class II histocompatibility antigen, DP beta 1 chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 200 of HLA class II histocompatibility antigen, DP beta 1 chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within HLA class II histocompatibility antigen, DP beta 1 chain between cysteines 44 and 106 (15 and 79 respectively in this structure).

Details

Redox score ?
79
PDB code
7t2a
Structure name
crystal structure of hla-dp4 in complex with ply
Structure deposition date
2021-12-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide accession
P04440
Residue number A
44
Residue number B
106
Peptide name
HLA class II histocompatibility antigen, DP beta 1 chain

Ligandability

Cysteine 44 of HLA class II histocompatibility antigen, DP beta 1 chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 106 of HLA class II histocompatibility antigen, DP beta 1 chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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