High affinity nerve growth factor receptor
Intermolecular
Cysteine 579 and cysteine 501
Intramolecular
Cysteine 36 and cysteine 41
Cysteine 154 and cysteine 191
Cysteine 40 and cysteine 50
Cysteine 152 and cysteine 177
Cysteine 300 and cysteine 442
Cysteine 215 and cysteine 265
Cysteine 300 and cysteine 345
Cysteine 36 and cysteine 40
Cysteine 40 and cysteine 41
More...Cysteine 41 and cysteine 50
Cysteine 36 and cysteine 50
Cysteine 529 and cysteine 579
Cysteine 152 and cysteine 191
6pme B 579 C 501
A redox-regulated disulphide may form between two units of High affinity nerve growth factor receptor at cysteines 579 and 501.
Details
Redox score ?
84
PDB code
6pme
Structure name
trk-a in complex with ligand
Structure deposition date
2019-07-01
Thiol separation (Å)
4
Half-sphere exposure sum ?
62
Minimum pKa ?
3
% buried
59
Peptide A name
High affinity nerve growth factor receptor
Peptide B name
High affinity nerve growth factor receptor
Peptide A accession
P04629
Peptide B accession
P04629
Peptide A residue number
579
Peptide B residue number
501
Ligandability
Cysteine 579 of High affinity nerve growth factor receptor
Cysteine 501 of High affinity nerve growth factor receptor
2ifg A 36 A 41
A redox-regulated disulphide may form within High affinity nerve growth factor receptor between cysteines 36 and 41.
Details
Redox score ?
89
PDB code
2ifg
Structure name
structure of the extracellular segment of human trka in complex with nerve growth factor
Structure deposition date
2006-09-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P04629
Residue number A
36
Residue number B
41
Peptide name
High affinity nerve growth factor receptor
Ligandability
Cysteine 36 of High affinity nerve growth factor receptor
Cysteine 41 of High affinity nerve growth factor receptor
2ifg A 154 A 191
A redox-regulated disulphide may form within High affinity nerve growth factor receptor between cysteines 154 and 191.
Details
Redox score ?
86
PDB code
2ifg
Structure name
structure of the extracellular segment of human trka in complex with nerve growth factor
Structure deposition date
2006-09-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
P04629
Residue number A
154
Residue number B
191
Peptide name
High affinity nerve growth factor receptor
Ligandability
Cysteine 154 of High affinity nerve growth factor receptor
Cysteine 191 of High affinity nerve growth factor receptor
2ifg A 40 A 50
A redox-regulated disulphide may form within High affinity nerve growth factor receptor between cysteines 40 and 50.
Details
Redox score ?
85
PDB code
2ifg
Structure name
structure of the extracellular segment of human trka in complex with nerve growth factor
Structure deposition date
2006-09-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
P04629
Residue number A
40
Residue number B
50
Peptide name
High affinity nerve growth factor receptor
Ligandability
Cysteine 40 of High affinity nerve growth factor receptor
Cysteine 50 of High affinity nerve growth factor receptor
7n3t A 152 A 177
A redox-regulated disulphide may form within High affinity nerve growth factor receptor between cysteines 152 and 177.
Details
Redox score ?
84
PDB code
7n3t
Structure name
trka ecd complex with designed miniprotein ligand
Structure deposition date
2021-06-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
P04629
Residue number A
152
Residue number B
177
Peptide name
High affinity nerve growth factor receptor
Ligandability
Cysteine 152 of High affinity nerve growth factor receptor
Cysteine 177 of High affinity nerve growth factor receptor
4crp A 9 A 91
A redox-regulated disulphide may form within High affinity nerve growth factor receptor between cysteines 300 and 442 (9 and 91 respectively in this structure).
Details
Redox score ?
84
PDB code
4crp
Structure name
solution structure of a trkaig2 domain construct for use in drug discovery
Structure deposition date
2014-02-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
44
Minimum pKa ?
nan
% buried
nan
Peptide accession
P04629
Residue number A
300
Residue number B
442
Peptide name
High affinity nerve growth factor receptor
Ligandability
Cysteine 300 of High affinity nerve growth factor receptor
Cysteine 442 of High affinity nerve growth factor receptor
Uncertain whether structure cysteine 9 has been assigned to correct residue.
2ifg B 215 B 265
A redox-regulated disulphide may form within High affinity nerve growth factor receptor between cysteines 215 and 265.
Details
Redox score ?
83
PDB code
2ifg
Structure name
structure of the extracellular segment of human trka in complex with nerve growth factor
Structure deposition date
2006-09-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
P04629
Residue number A
215
Residue number B
265
Peptide name
High affinity nerve growth factor receptor
Ligandability
Cysteine 215 of High affinity nerve growth factor receptor
Cysteine 265 of High affinity nerve growth factor receptor
1wwa X 300 X 345
A redox-regulated disulphide may form within High affinity nerve growth factor receptor between cysteines 300 and 345.
Details
Redox score ?
81
PDB code
1wwa
Structure name
ngf binding domain of human trka receptor
Structure deposition date
1999-04-29
Thiol separation (Å)
2
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
P04629
Residue number A
300
Residue number B
345
Peptide name
High affinity nerve growth factor receptor
Ligandability
Cysteine 300 of High affinity nerve growth factor receptor
Cysteine 345 of High affinity nerve growth factor receptor
7n3t A 36 A 40
A redox-regulated disulphide may form within High affinity nerve growth factor receptor between cysteines 36 and 40. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
53
PDB code
7n3t
Structure name
trka ecd complex with designed miniprotein ligand
Structure deposition date
2021-06-01
Thiol separation (Å)
8
Half-sphere exposure sum ?
43
Minimum pKa ?
nan
% buried
nan
Peptide accession
P04629
Residue number A
36
Residue number B
40
Peptide name
High affinity nerve growth factor receptor
Ligandability
Cysteine 36 of High affinity nerve growth factor receptor
Cysteine 40 of High affinity nerve growth factor receptor
7n3t A 40 A 41
A redox-regulated disulphide may form within High affinity nerve growth factor receptor between cysteines 40 and 41. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
53
PDB code
7n3t
Structure name
trka ecd complex with designed miniprotein ligand
Structure deposition date
2021-06-01
Thiol separation (Å)
7
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
P04629
Residue number A
40
Residue number B
41
Peptide name
High affinity nerve growth factor receptor
Ligandability
Cysteine 40 of High affinity nerve growth factor receptor
Cysteine 41 of High affinity nerve growth factor receptor
7n3t A 41 A 50
A redox-regulated disulphide may form within High affinity nerve growth factor receptor between cysteines 41 and 50. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
7n3t
Structure name
trka ecd complex with designed miniprotein ligand
Structure deposition date
2021-06-01
Thiol separation (Å)
8
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
P04629
Residue number A
41
Residue number B
50
Peptide name
High affinity nerve growth factor receptor
Ligandability
Cysteine 41 of High affinity nerve growth factor receptor
Cysteine 50 of High affinity nerve growth factor receptor
7n3t A 36 A 50
A redox-regulated disulphide may form within High affinity nerve growth factor receptor between cysteines 36 and 50. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
7n3t
Structure name
trka ecd complex with designed miniprotein ligand
Structure deposition date
2021-06-01
Thiol separation (Å)
9
Half-sphere exposure sum ?
47
Minimum pKa ?
nan
% buried
nan
Peptide accession
P04629
Residue number A
36
Residue number B
50
Peptide name
High affinity nerve growth factor receptor
Ligandability
Cysteine 36 of High affinity nerve growth factor receptor
Cysteine 50 of High affinity nerve growth factor receptor
5kmo A 529 A 579
A redox-regulated disulphide may form within High affinity nerve growth factor receptor between cysteines 529 and 579. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
5kmo
Structure name
trka jm-kinase with 1-(2-methyl-4-phenyl-pyrimidin-5-yl)-3-(2- pyridyl)urea
Structure deposition date
2016-06-27
Thiol separation (Å)
9
Half-sphere exposure sum ?
63
Minimum pKa ?
10
% buried
40
Peptide accession
P04629
Residue number A
529
Residue number B
579
Peptide name
High affinity nerve growth factor receptor
Ligandability
Cysteine 529 of High affinity nerve growth factor receptor
Cysteine 579 of High affinity nerve growth factor receptor
7n3t A 152 A 191
A redox-regulated disulphide may form within High affinity nerve growth factor receptor between cysteines 152 and 191. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
7n3t
Structure name
trka ecd complex with designed miniprotein ligand
Structure deposition date
2021-06-01
Thiol separation (Å)
10
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
P04629
Residue number A
152
Residue number B
191
Peptide name
High affinity nerve growth factor receptor
Ligandability
Cysteine 152 of High affinity nerve growth factor receptor
Cysteine 191 of High affinity nerve growth factor receptor
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