ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Guanine nucleotide-binding protein G(i) subunit alpha-2

Intermolecular
Cysteine 126 of N-formyl peptide receptor 2 and cysteine 352
Cysteine 63 of N-formyl peptide receptor 2 and cysteine 352
A redox-regulated disulphide may form between cysteine 126 of N-formyl peptide receptor 2 and cysteine 352 of Guanine nucleotide-binding protein G(i) subunit alpha-2. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
7wvv
Structure name
cryo-em structure of the human formyl peptide receptor 2 in complex with fmlfii and gi2
Structure deposition date
2022-02-11
Thiol separation (Å)
8
Half-sphere exposure sum ?
74
Minimum pKa ?
10
% buried
93
Peptide A name
N-formyl peptide receptor 2
Peptide B name
Guanine nucleotide-binding protein G(i) subunit alpha-2
Peptide A accession
P25090
Peptide B accession
P04899
Peptide A residue number
126
Peptide B residue number
352

Ligandability

Cysteine 126 of N-formyl peptide receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 352 of Guanine nucleotide-binding protein G(i) subunit alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 63 of N-formyl peptide receptor 2 and cysteine 352 of Guanine nucleotide-binding protein G(i) subunit alpha-2. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
7wvy
Structure name
cryo-em structure of the human formyl peptide receptor 2 in complex with abeta42 and gi2
Structure deposition date
2022-02-11
Thiol separation (Å)
9
Half-sphere exposure sum ?
79
Minimum pKa ?
10
% buried
94
Peptide A name
N-formyl peptide receptor 2
Peptide B name
Guanine nucleotide-binding protein G(i) subunit alpha-2
Peptide A accession
P25090
Peptide B accession
P04899
Peptide A residue number
63
Peptide B residue number
352

Ligandability

Cysteine 63 of N-formyl peptide receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 352 of Guanine nucleotide-binding protein G(i) subunit alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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