ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Fructose-bisphosphate aldolase B

Intramolecular
Cysteine 135 and cysteine 178
Cysteine 202 and cysteine 240
A redox-regulated disulphide may form within Fructose-bisphosphate aldolase B between cysteines 135 and 178 (134 and 177 respectively in this structure).

Details

Redox score ?
69
PDB code
1qo5
Structure name
fructose 1,6-bisphosphate aldolase from human liver tissue
Structure deposition date
1999-11-03
Thiol separation (Å)
4
Half-sphere exposure sum ?
85
Minimum pKa ?
9
% buried
96
Peptide accession
P05062
Residue number A
135
Residue number B
178
Peptide name
Fructose-bisphosphate aldolase B

Ligandability

Cysteine 135 of Fructose-bisphosphate aldolase B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 178 of Fructose-bisphosphate aldolase B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Fructose-bisphosphate aldolase B between cysteines 202 and 240. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
8d44
Structure name
cryo-electron microscopy structure of human kidney fructose- bisphosphate aldolase b
Structure deposition date
2022-06-01
Thiol separation (Å)
10
Half-sphere exposure sum ?
55
Minimum pKa ?
9
% buried
43
Peptide accession
P05062
Residue number A
202
Residue number B
240
Peptide name
Fructose-bisphosphate aldolase B

Ligandability

Cysteine 202 of Fructose-bisphosphate aldolase B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 240 of Fructose-bisphosphate aldolase B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: