ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Apolipoprotein D

Intramolecular
Cysteine 61 and cysteine 185
Cysteine 28 and cysteine 134
A redox-regulated disulphide may form within Apolipoprotein D between cysteines 61 and 185 (41 and 165 respectively in this structure).

Details

Redox score ?
85
PDB code
2hzr
Structure name
crystal structure of human apolipoprotein d (apod)
Structure deposition date
2006-08-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
P05090
Residue number A
61
Residue number B
185
Peptide name
Apolipoprotein D

Ligandability

Cysteine 61 of Apolipoprotein D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 185 of Apolipoprotein D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Apolipoprotein D between cysteines 28 and 134 (8 and 114 respectively in this structure).

Details

Redox score ?
84
PDB code
2hzr
Structure name
crystal structure of human apolipoprotein d (apod)
Structure deposition date
2006-08-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
P05090
Residue number A
28
Residue number B
134
Peptide name
Apolipoprotein D

Ligandability

Cysteine 28 of Apolipoprotein D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 134 of Apolipoprotein D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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