Steroid 17-alpha-hydroxylase/17,20 lyase

Intramolecular

A redox-regulated disulphide may form within Steroid 17-alpha-hydroxylase/17,20 lyase between cysteines 147 and 154. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

6ww0

Structure name

human steroidogenic cytochrome p450 17a1 with 3-keto-5alpha- abiraterone analog

Structure deposition date

2020-05-07

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

P05093

Residue number A

147

Residue number B

154

Peptide name

Steroid 17-alpha-hydroxylase/17,20 lyase

Ligandability

Cysteine 147 of Steroid 17-alpha-hydroxylase/17,20 lyase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.