Interleukin-4
Intermolecular
Cysteine 27 and cysteine 231 of Cytokine receptor common subunit gamma
Cysteine 27 and cysteine 182 of Cytokine receptor common subunit gamma
Cysteine 151 and cysteine 257 of Interleukin-13 receptor subunit alpha-1
Cysteine 151 and cysteine 231 of Cytokine receptor common subunit gamma
Cysteine 151 and cysteine 320 of Interleukin-13 receptor subunit alpha-1
Cysteine 151 and cysteine 182 of Cytokine receptor common subunit gamma
Intramolecular
Cysteine 27 and cysteine 151
Cysteine 48 and cysteine 89
Cysteine 70 and cysteine 123
3bpl A 3 C 209
A redox-regulated disulphide may form between cysteine 27 of Interleukin-4 and cysteine 231 of Cytokine receptor common subunit gamma (3 and 209 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
52
PDB code
3bpl
Structure name
crystal structure of the il4-il4r-common gamma ternary complex
Structure deposition date
2007-12-18
Thiol separation (Å)
8
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide A name
Interleukin-4
Peptide B name
Cytokine receptor common subunit gamma
Peptide A accession
P05112
Peptide B accession
P31785
Peptide A residue number
27
Peptide B residue number
231
Ligandability
Cysteine 27 of Interleukin-4
Cysteine 231 of Cytokine receptor common subunit gamma
3bpl A 3 C 160
A redox-regulated disulphide may form between cysteine 27 of Interleukin-4 and cysteine 182 of Cytokine receptor common subunit gamma (3 and 160 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
50
PDB code
3bpl
Structure name
crystal structure of the il4-il4r-common gamma ternary complex
Structure deposition date
2007-12-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide A name
Interleukin-4
Peptide B name
Cytokine receptor common subunit gamma
Peptide A accession
P05112
Peptide B accession
P31785
Peptide A residue number
27
Peptide B residue number
182
Ligandability
Cysteine 27 of Interleukin-4
Cysteine 182 of Cytokine receptor common subunit gamma
3bpn A 127 C 257
A redox-regulated disulphide may form between cysteine 151 of Interleukin-4 and cysteine 257 of Interleukin-13 receptor subunit alpha-1 (127 and 257 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
3bpn
Structure name
crystal structure of the il4-il4r-il13ra ternary complex
Structure deposition date
2007-12-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide A name
Interleukin-4
Peptide B name
Interleukin-13 receptor subunit alpha-1
Peptide A accession
P05112
Peptide B accession
P78552
Peptide A residue number
151
Peptide B residue number
257
Ligandability
Cysteine 151 of Interleukin-4
Cysteine 257 of Interleukin-13 receptor subunit alpha-1
3bpl A 127 C 209
A redox-regulated disulphide may form between cysteine 151 of Interleukin-4 and cysteine 231 of Cytokine receptor common subunit gamma (127 and 209 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
3bpl
Structure name
crystal structure of the il4-il4r-common gamma ternary complex
Structure deposition date
2007-12-18
Thiol separation (Å)
8
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide A name
Interleukin-4
Peptide B name
Cytokine receptor common subunit gamma
Peptide A accession
P05112
Peptide B accession
P31785
Peptide A residue number
151
Peptide B residue number
231
Ligandability
Cysteine 151 of Interleukin-4
Cysteine 231 of Cytokine receptor common subunit gamma
3bpn A 127 C 320
A redox-regulated disulphide may form between cysteine 151 of Interleukin-4 and cysteine 320 of Interleukin-13 receptor subunit alpha-1 (127 and 320 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
3bpn
Structure name
crystal structure of the il4-il4r-il13ra ternary complex
Structure deposition date
2007-12-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide A name
Interleukin-4
Peptide B name
Interleukin-13 receptor subunit alpha-1
Peptide A accession
P05112
Peptide B accession
P78552
Peptide A residue number
151
Peptide B residue number
320
Ligandability
Cysteine 151 of Interleukin-4
Cysteine 320 of Interleukin-13 receptor subunit alpha-1
3bpl A 127 C 160
A redox-regulated disulphide may form between cysteine 151 of Interleukin-4 and cysteine 182 of Cytokine receptor common subunit gamma (127 and 160 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
3bpl
Structure name
crystal structure of the il4-il4r-common gamma ternary complex
Structure deposition date
2007-12-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide A name
Interleukin-4
Peptide B name
Cytokine receptor common subunit gamma
Peptide A accession
P05112
Peptide B accession
P31785
Peptide A residue number
151
Peptide B residue number
182
Ligandability
Cysteine 151 of Interleukin-4
Cysteine 182 of Cytokine receptor common subunit gamma
2b90 A 3 A 127
A redox-regulated disulphide may form within Interleukin-4 between cysteines 27 and 151 (3 and 127 respectively in this structure).
Details
Redox score ?
88
PDB code
2b90
Structure name
crystal structure of the interleukin-4 variant t13dr85a
Structure deposition date
2005-10-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
34
Minimum pKa ?
nan
% buried
nan
Peptide accession
P05112
Residue number A
27
Residue number B
151
Peptide name
Interleukin-4
Ligandability
Cysteine 27 of Interleukin-4
Cysteine 151 of Interleukin-4
1hik A 24 A 65
A redox-regulated disulphide may form within Interleukin-4 between cysteines 48 and 89 (24 and 65 respectively in this structure).
Details
Redox score ?
86
PDB code
1hik
Structure name
interleukin-4 (wild-type)
Structure deposition date
1995-06-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
P05112
Residue number A
48
Residue number B
89
Peptide name
Interleukin-4
Ligandability
Cysteine 48 of Interleukin-4
Cysteine 89 of Interleukin-4
1iar A 46 A 99
A redox-regulated disulphide may form within Interleukin-4 between cysteines 70 and 123 (46 and 99 respectively in this structure).
Details
Redox score ?
85
PDB code
1iar
Structure name
interleukin-4 / receptor alpha chain complex
Structure deposition date
1999-02-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
P05112
Residue number A
70
Residue number B
123
Peptide name
Interleukin-4
Ligandability
Cysteine 70 of Interleukin-4
Cysteine 123 of Interleukin-4
If this tool was useful for finding a disulphide, please cite: