ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Plasma protease C1 inhibitor

Intramolecular
Cysteine 130 and cysteine 205
Cysteine 123 and cysteine 428
A redox-regulated disulphide may form within Plasma protease C1 inhibitor between cysteines 130 and 205 (108 and 183 respectively in this structure).

Details

Redox score ?
87
PDB code
2oay
Structure name
crystal structure of latent human c1-inhibitor
Structure deposition date
2006-12-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
49
Minimum pKa ?
nan
% buried
nan
Peptide accession
P05155
Residue number A
130
Residue number B
205
Peptide name
Plasma protease C1 inhibitor

Ligandability

Cysteine 130 of Plasma protease C1 inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 205 of Plasma protease C1 inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Plasma protease C1 inhibitor between cysteines 123 and 428 (101 and 406 respectively in this structure).

Details

Redox score ?
84
PDB code
5du3
Structure name
active form of human c1-inhibitor
Structure deposition date
2015-09-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
P05155
Residue number A
123
Residue number B
428
Peptide name
Plasma protease C1 inhibitor

Ligandability

Cysteine 123 of Plasma protease C1 inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 428 of Plasma protease C1 inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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