ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Alkaline phosphatase, placental type

Intramolecular
Cysteine 143 and cysteine 205
Cysteine 489 and cysteine 496
A redox-regulated disulphide may form within Alkaline phosphatase, placental type between cysteines 143 and 205 (121 and 183 respectively in this structure).

Details

Redox score ?
86
PDB code
3mk0
Structure name
refinement of placental alkaline phosphatase complexed with nitrophenyl
Structure deposition date
2010-04-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
P05187
Residue number A
143
Residue number B
205
Peptide name
Alkaline phosphatase, placental type

Ligandability

Cysteine 143 of Alkaline phosphatase, placental type

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 205 of Alkaline phosphatase, placental type

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Alkaline phosphatase, placental type between cysteines 489 and 496 (467 and 474 respectively in this structure).

Details

Redox score ?
84
PDB code
3mk2
Structure name
placental alkaline phosphatase complexed with phe
Structure deposition date
2010-04-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
P05187
Residue number A
489
Residue number B
496
Peptide name
Alkaline phosphatase, placental type

Ligandability

Cysteine 489 of Alkaline phosphatase, placental type

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 496 of Alkaline phosphatase, placental type

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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