ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Eukaryotic translation initiation factor 2 subunit 1

Intramolecular
Cysteine 70 and cysteine 98
Cysteine 6 and cysteine 98
A redox-regulated disulphide may form within Eukaryotic translation initiation factor 2 subunit 1 between cysteines 70 and 98 (69 and 97 respectively in this structure).

Details

Redox score ?
70
PDB code
1q8k
Structure name
solution structure of alpha subunit of human eif2
Structure deposition date
2003-08-21
Thiol separation (Å)
4
Half-sphere exposure sum ?
66
Minimum pKa ?
11
% buried
47
Peptide accession
P05198
Residue number A
70
Residue number B
98
Peptide name
Eukaryotic translation initiation factor 2 subunit 1

Ligandability

Cysteine 70 of Eukaryotic translation initiation factor 2 subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 98 of Eukaryotic translation initiation factor 2 subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Eukaryotic translation initiation factor 2 subunit 1 between cysteines 6 and 98 (5 and 97 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
1q8k
Structure name
solution structure of alpha subunit of human eif2
Structure deposition date
2003-08-21
Thiol separation (Å)
8
Half-sphere exposure sum ?
57
Minimum pKa ?
11
% buried
54
Peptide accession
P05198
Residue number A
6
Residue number B
98
Peptide name
Eukaryotic translation initiation factor 2 subunit 1

Ligandability

Cysteine 6 of Eukaryotic translation initiation factor 2 subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 98 of Eukaryotic translation initiation factor 2 subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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