ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Fibroblast growth factor 1

Intramolecular
Cysteine 66 and cysteine 98
Cysteine 31 and cysteine 132
Cysteine 98 and cysteine 132
A redox-regulated disulphide may form within Fibroblast growth factor 1 between cysteines 66 and 98 (66 and 83 respectively in this structure).

Details

Redox score ?
61
PDB code
3fjk
Structure name
crystal structure of a66c mutant of human acidic fibroblast growth factor
Structure deposition date
2008-12-14
Thiol separation (Å)
5
Half-sphere exposure sum ?
79
Minimum pKa ?
10
% buried
48
Peptide accession
P05230
Residue number A
66
Residue number B
98
Peptide name
Fibroblast growth factor 1

Ligandability

Cysteine 66 of Fibroblast growth factor 1

Cysteine 98 of Fibroblast growth factor 1

Cysteine 66 in protein A could not be asigned to a Uniprot residue.
A redox-regulated disulphide may form within Fibroblast growth factor 1 between cysteines 31 and 132 (16 and 117 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
1p63
Structure name
human acidic fibroblast growth factor
Structure deposition date
2003-04-28
Thiol separation (Å)
9
Half-sphere exposure sum ?
77
Minimum pKa ?
11
% buried
88
Peptide accession
P05230
Residue number A
31
Residue number B
132
Peptide name
Fibroblast growth factor 1

Ligandability

Cysteine 31 of Fibroblast growth factor 1

Cysteine 132 of Fibroblast growth factor 1

A redox-regulated disulphide may form within Fibroblast growth factor 1 between cysteines 98 and 132 (76 and 110 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
2k4a
Structure name
fgf-1-c2a binary complex structure: a key component in the fibroblast growthfactor non-classical pathway
Structure deposition date
2008-06-02
Thiol separation (Å)
10
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide accession
P05230
Residue number A
98
Residue number B
132
Peptide name
Fibroblast growth factor 1

Ligandability

Cysteine 98 of Fibroblast growth factor 1

Cysteine 132 of Fibroblast growth factor 1

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