ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Interleukin-6

Intramolecular
Cysteine 72 and cysteine 78
Cysteine 101 and cysteine 111
A redox-regulated disulphide may form within Interleukin-6 between cysteines 72 and 78 (44 and 50 respectively in this structure).

Details

Redox score ?
88
PDB code
4j4l
Structure name
modular evolution and design of the protein binding interface
Structure deposition date
2013-02-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
44
Minimum pKa ?
nan
% buried
nan
Peptide accession
P05231
Residue number A
72
Residue number B
78
Peptide name
Interleukin-6

Ligandability

Cysteine 72 of Interleukin-6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 78 of Interleukin-6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interleukin-6 between cysteines 101 and 111 (73 and 83 respectively in this structure).

Details

Redox score ?
86
PDB code
4ni7
Structure name
crystal structure of human interleukin 6 in complex with a modified nucleotide aptamer (somamer sl1025)
Structure deposition date
2013-11-05
Thiol separation (Å)
2
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
P05231
Residue number A
101
Residue number B
111
Peptide name
Interleukin-6

Ligandability

Cysteine 101 of Interleukin-6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 111 of Interleukin-6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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