a tool for identifying drug-targetable redox-active disulphides

DNA-directed RNA polymerase III subunit RPC4

Intermolecular

Cysteine 527 of DNA-directed RNA polymerase III subunit RPC2 and cysteine 354

A redox-regulated disulphide may form between cysteine 527 of DNA-directed RNA polymerase III subunit RPC2 and cysteine 354 of DNA-directed RNA polymerase III subunit RPC4. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

32

PDB code

Structure name

cryo-em structure of human apo rna polymerase iii

Structure deposition date

2020-08-25

Thiol separation (Å)

9

Half-sphere exposure sum ?

80

Minimum pK_a ?

12

% buried

100

Peptide A name

DNA-directed RNA polymerase III subunit RPC2

Peptide B name

DNA-directed RNA polymerase III subunit RPC4

Peptide A accession

Peptide B accession

Peptide A residue number

527

Peptide B residue number

354

Ligandability

Cysteine 527 of DNA-directed RNA polymerase III subunit RPC2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 354 of DNA-directed RNA polymerase III subunit RPC4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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