ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Tetranectin

Intramolecular
Cysteine 98 and cysteine 197 L
Cysteine 71 and cysteine 81
Cysteine 173 and cysteine 189
A redox-regulated disulphide may form within Tetranectin between cysteines 98 and 197 (77 and 176 respectively in this structure).

Details

Redox score ?
82
PDB code
1tn3
Structure name
the c-type lectin carbohydrate recognition domain of human tetranectin
Structure deposition date
1997-11-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
P05452
Residue number A
98
Residue number B
197
Peptide name
Tetranectin

Ligandability

Cysteine 98 of Tetranectin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 197 of Tetranectin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tetranectin between cysteines 71 and 81 (50 and 60 respectively in this structure).

Details

Redox score ?
82
PDB code
1htn
Structure name
human tetranectin, a trimeric plasminogen binding protein with an alpha-helical coiled coil
Structure deposition date
1997-05-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
P05452
Residue number A
71
Residue number B
81
Peptide name
Tetranectin

Ligandability

Cysteine 71 of Tetranectin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 81 of Tetranectin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tetranectin between cysteines 173 and 189 (152 and 168 respectively in this structure).

Details

Redox score ?
81
PDB code
1htn
Structure name
human tetranectin, a trimeric plasminogen binding protein with an alpha-helical coiled coil
Structure deposition date
1997-05-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
P05452
Residue number A
173
Residue number B
189
Peptide name
Tetranectin

Ligandability

Cysteine 173 of Tetranectin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 189 of Tetranectin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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