a tool for identifying drug-targetable redox-active disulphides

Thyroxine-binding globulin

Intramolecular

Cysteine 85 and cysteine 86

A redox-regulated disulphide may form within Thyroxine-binding globulin between cysteines 85 and 86 (65 and 66 respectively in this structure).

Details

Redox score ?

60

PDB code

Structure name

thyroxine-binding globulin complex with thyroxine

Structure deposition date

2006-02-08

Thiol separation (Å)

6

Half-sphere exposure sum ?

45

Minimum pK_a ?

9

% buried

8

Peptide accession

Residue number A

85

Residue number B

86

Peptide name

Thyroxine-binding globulin

Ligandability

Cysteine 85 of Thyroxine-binding globulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 86 of Thyroxine-binding globulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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