ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Integrin beta-1

Intramolecular
Cysteine 699 and cysteine 723
Cysteine 649 and cysteine 661
Cysteine 633 and cysteine 636
Cysteine 607 and cysteine 618
Cysteine 35 and cysteine 464
Cysteine 599 and cysteine 613
Cysteine 207 and cysteine 213
Cysteine 560 and cysteine 574
Cysteine 401 and cysteine 415
Cysteine 620 and cysteine 630
More...
Cysteine 538 and cysteine 553
Cysteine 568 and cysteine 579
Cysteine 27 and cysteine 45
Cysteine 581 and cysteine 590
Cysteine 516 and cysteine 531
Cysteine 491 and cysteine 500
Cysteine 525 and cysteine 536
Cysteine 646 and cysteine 665
Cysteine 640 and cysteine 691
Cysteine 435 and cysteine 462
Cysteine 261 and cysteine 301
Cysteine 502 and cysteine 533
Cysteine 466 and cysteine 486
Cysteine 477 and cysteine 489
Cysteine 555 and cysteine 576
Cysteine 38 and cysteine 64
Cysteine 592 and cysteine 615
Cysteine 486 and cysteine 261
Cysteine 599 and cysteine 618
Cysteine 568 and cysteine 574
Cysteine 599 and cysteine 607
Cysteine 516 and cysteine 536
Cysteine 516 and cysteine 525
Cysteine 560 and cysteine 568
Cysteine 574 and cysteine 579
Cysteine 613 and cysteine 618
Cysteine 560 and cysteine 579
Cysteine 607 and cysteine 613
Cysteine 525 and cysteine 531
Cysteine 489 and cysteine 500
A redox-regulated disulphide may form within Integrin beta-1 between cysteines 699 and 723 (679 and 703 respectively in this structure).

Details

Redox score ?
91
PDB code
7nxd
Structure name
cryo-em structure of human integrin alpha5beta1 in the half-bent conformation
Structure deposition date
2021-03-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P05556
Residue number A
699
Residue number B
723
Peptide name
Integrin beta-1

Ligandability

Cysteine 699 of Integrin beta-1

Cysteine 723 of Integrin beta-1

A redox-regulated disulphide may form within Integrin beta-1 between cysteines 649 and 661 (629 and 641 respectively in this structure).

Details

Redox score ?
90
PDB code
7nxd
Structure name
cryo-em structure of human integrin alpha5beta1 in the half-bent conformation
Structure deposition date
2021-03-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P05556
Residue number A
649
Residue number B
661
Peptide name
Integrin beta-1

Ligandability

Cysteine 649 of Integrin beta-1

Cysteine 661 of Integrin beta-1

A redox-regulated disulphide may form within Integrin beta-1 between cysteines 633 and 636 (613 and 616 respectively in this structure).

Details

Redox score ?
89
PDB code
7nxd
Structure name
cryo-em structure of human integrin alpha5beta1 in the half-bent conformation
Structure deposition date
2021-03-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
45
Minimum pKa ?
nan
% buried
nan
Peptide accession
P05556
Residue number A
633
Residue number B
636
Peptide name
Integrin beta-1

Ligandability

Cysteine 633 of Integrin beta-1

Cysteine 636 of Integrin beta-1

A redox-regulated disulphide may form within Integrin beta-1 between cysteines 607 and 618 (587 and 598 respectively in this structure).

Details

Redox score ?
88
PDB code
7nxd
Structure name
cryo-em structure of human integrin alpha5beta1 in the half-bent conformation
Structure deposition date
2021-03-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
P05556
Residue number A
607
Residue number B
618
Peptide name
Integrin beta-1

Ligandability

Cysteine 607 of Integrin beta-1

Cysteine 618 of Integrin beta-1

A redox-regulated disulphide may form within Integrin beta-1 between cysteines 35 and 464 (15 and 444 respectively in this structure).

Details

Redox score ?
88
PDB code
3vi4
Structure name
crystal structure of alpha5beta1 integrin headpiece in complex with rgd peptide
Structure deposition date
2011-09-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
40
Minimum pKa ?
nan
% buried
nan
Peptide accession
P05556
Residue number A
35
Residue number B
464
Peptide name
Integrin beta-1

Ligandability

Cysteine 35 of Integrin beta-1

Cysteine 464 of Integrin beta-1

A redox-regulated disulphide may form within Integrin beta-1 between cysteines 599 and 613 (579 and 593 respectively in this structure).

Details

Redox score ?
87
PDB code
7nxd
Structure name
cryo-em structure of human integrin alpha5beta1 in the half-bent conformation
Structure deposition date
2021-03-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
P05556
Residue number A
599
Residue number B
613
Peptide name
Integrin beta-1

Ligandability

Cysteine 599 of Integrin beta-1

Cysteine 613 of Integrin beta-1

A redox-regulated disulphide may form within Integrin beta-1 between cysteines 207 and 213 (187 and 193 respectively in this structure).

Details

Redox score ?
87
PDB code
7ceb
Structure name
crystal structure of alpha6beta1 integrin headpiece
Structure deposition date
2020-06-22
Thiol separation (Å)
2
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
P05556
Residue number A
207
Residue number B
213
Peptide name
Integrin beta-1

Ligandability

Cysteine 207 of Integrin beta-1

Cysteine 213 of Integrin beta-1

A redox-regulated disulphide may form within Integrin beta-1 between cysteines 560 and 574 (540 and 554 respectively in this structure).

Details

Redox score ?
86
PDB code
7nxd
Structure name
cryo-em structure of human integrin alpha5beta1 in the half-bent conformation
Structure deposition date
2021-03-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
P05556
Residue number A
560
Residue number B
574
Peptide name
Integrin beta-1

Ligandability

Cysteine 560 of Integrin beta-1

Cysteine 574 of Integrin beta-1

A redox-regulated disulphide may form within Integrin beta-1 between cysteines 401 and 415 (381 and 395 respectively in this structure).

Details

Redox score ?
86
PDB code
4wk4
Structure name
metal ion and ligand binding of integrin
Structure deposition date
2014-10-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
P05556
Residue number A
401
Residue number B
415
Peptide name
Integrin beta-1

Ligandability

Cysteine 401 of Integrin beta-1

Cysteine 415 of Integrin beta-1

A redox-regulated disulphide may form within Integrin beta-1 between cysteines 620 and 630 (600 and 610 respectively in this structure).

Details

Redox score ?
86
PDB code
7nxd
Structure name
cryo-em structure of human integrin alpha5beta1 in the half-bent conformation
Structure deposition date
2021-03-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
P05556
Residue number A
620
Residue number B
630
Peptide name
Integrin beta-1

Ligandability

Cysteine 620 of Integrin beta-1

Cysteine 630 of Integrin beta-1

A redox-regulated disulphide may form within Integrin beta-1 between cysteines 538 and 553 (518 and 533 respectively in this structure).

Details

Redox score ?
86
PDB code
7nxd
Structure name
cryo-em structure of human integrin alpha5beta1 in the half-bent conformation
Structure deposition date
2021-03-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
P05556
Residue number A
538
Residue number B
553
Peptide name
Integrin beta-1

Ligandability

Cysteine 538 of Integrin beta-1

Cysteine 553 of Integrin beta-1

A redox-regulated disulphide may form within Integrin beta-1 between cysteines 568 and 579 (548 and 559 respectively in this structure).

Details

Redox score ?
86
PDB code
7nxd
Structure name
cryo-em structure of human integrin alpha5beta1 in the half-bent conformation
Structure deposition date
2021-03-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
P05556
Residue number A
568
Residue number B
579
Peptide name
Integrin beta-1

Ligandability

Cysteine 568 of Integrin beta-1

Cysteine 579 of Integrin beta-1

A redox-regulated disulphide may form within Integrin beta-1 between cysteines 27 and 45 (7 and 25 respectively in this structure).

Details

Redox score ?
85
PDB code
4wk2
Structure name
metal ion and ligand binding of integrin
Structure deposition date
2014-10-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
P05556
Residue number A
27
Residue number B
45
Peptide name
Integrin beta-1

Ligandability

Cysteine 27 of Integrin beta-1

Cysteine 45 of Integrin beta-1

A redox-regulated disulphide may form within Integrin beta-1 between cysteines 581 and 590 (561 and 570 respectively in this structure).

Details

Redox score ?
85
PDB code
7nxd
Structure name
cryo-em structure of human integrin alpha5beta1 in the half-bent conformation
Structure deposition date
2021-03-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
P05556
Residue number A
581
Residue number B
590
Peptide name
Integrin beta-1

Ligandability

Cysteine 581 of Integrin beta-1

Cysteine 590 of Integrin beta-1

A redox-regulated disulphide may form within Integrin beta-1 between cysteines 516 and 531 (496 and 511 respectively in this structure).

Details

Redox score ?
85
PDB code
7nxd
Structure name
cryo-em structure of human integrin alpha5beta1 in the half-bent conformation
Structure deposition date
2021-03-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
P05556
Residue number A
516
Residue number B
531
Peptide name
Integrin beta-1

Ligandability

Cysteine 516 of Integrin beta-1

Cysteine 531 of Integrin beta-1

A redox-regulated disulphide may form within Integrin beta-1 between cysteines 491 and 500 (471 and 480 respectively in this structure).

Details

Redox score ?
85
PDB code
7nxd
Structure name
cryo-em structure of human integrin alpha5beta1 in the half-bent conformation
Structure deposition date
2021-03-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
P05556
Residue number A
491
Residue number B
500
Peptide name
Integrin beta-1

Ligandability

Cysteine 491 of Integrin beta-1

Cysteine 500 of Integrin beta-1

A redox-regulated disulphide may form within Integrin beta-1 between cysteines 525 and 536 (505 and 516 respectively in this structure).

Details

Redox score ?
85
PDB code
7nxd
Structure name
cryo-em structure of human integrin alpha5beta1 in the half-bent conformation
Structure deposition date
2021-03-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
P05556
Residue number A
525
Residue number B
536
Peptide name
Integrin beta-1

Ligandability

Cysteine 525 of Integrin beta-1

Cysteine 536 of Integrin beta-1

A redox-regulated disulphide may form within Integrin beta-1 between cysteines 646 and 665 (626 and 645 respectively in this structure).

Details

Redox score ?
85
PDB code
7nxd
Structure name
cryo-em structure of human integrin alpha5beta1 in the half-bent conformation
Structure deposition date
2021-03-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
P05556
Residue number A
646
Residue number B
665
Peptide name
Integrin beta-1

Ligandability

Cysteine 646 of Integrin beta-1

Cysteine 665 of Integrin beta-1

A redox-regulated disulphide may form within Integrin beta-1 between cysteines 640 and 691 (620 and 671 respectively in this structure).

Details

Redox score ?
85
PDB code
7nxd
Structure name
cryo-em structure of human integrin alpha5beta1 in the half-bent conformation
Structure deposition date
2021-03-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
P05556
Residue number A
640
Residue number B
691
Peptide name
Integrin beta-1

Ligandability

Cysteine 640 of Integrin beta-1

Cysteine 691 of Integrin beta-1

A redox-regulated disulphide may form within Integrin beta-1 between cysteines 435 and 462 (415 and 442 respectively in this structure).

Details

Redox score ?
84
PDB code
4wk2
Structure name
metal ion and ligand binding of integrin
Structure deposition date
2014-10-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
P05556
Residue number A
435
Residue number B
462
Peptide name
Integrin beta-1

Ligandability

Cysteine 435 of Integrin beta-1

Cysteine 462 of Integrin beta-1

A redox-regulated disulphide may form within Integrin beta-1 between cysteines 261 and 301 (241 and 281 respectively in this structure).

Details

Redox score ?
84
PDB code
7ceb
Structure name
crystal structure of alpha6beta1 integrin headpiece
Structure deposition date
2020-06-22
Thiol separation (Å)
2
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
P05556
Residue number A
261
Residue number B
301
Peptide name
Integrin beta-1

Ligandability

Cysteine 261 of Integrin beta-1

Cysteine 301 of Integrin beta-1

A redox-regulated disulphide may form within Integrin beta-1 between cysteines 502 and 533 (482 and 513 respectively in this structure).

Details

Redox score ?
84
PDB code
7nxd
Structure name
cryo-em structure of human integrin alpha5beta1 in the half-bent conformation
Structure deposition date
2021-03-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
P05556
Residue number A
502
Residue number B
533
Peptide name
Integrin beta-1

Ligandability

Cysteine 502 of Integrin beta-1

Cysteine 533 of Integrin beta-1

A redox-regulated disulphide may form within Integrin beta-1 between cysteines 466 and 486 (446 and 466 respectively in this structure).

Details

Redox score ?
83
PDB code
7nxd
Structure name
cryo-em structure of human integrin alpha5beta1 in the half-bent conformation
Structure deposition date
2021-03-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
P05556
Residue number A
466
Residue number B
486
Peptide name
Integrin beta-1

Ligandability

Cysteine 466 of Integrin beta-1

Cysteine 486 of Integrin beta-1

A redox-regulated disulphide may form within Integrin beta-1 between cysteines 477 and 489 (457 and 469 respectively in this structure).

Details

Redox score ?
83
PDB code
7nxd
Structure name
cryo-em structure of human integrin alpha5beta1 in the half-bent conformation
Structure deposition date
2021-03-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
P05556
Residue number A
477
Residue number B
489
Peptide name
Integrin beta-1

Ligandability

Cysteine 477 of Integrin beta-1

Cysteine 489 of Integrin beta-1

A redox-regulated disulphide may form within Integrin beta-1 between cysteines 555 and 576 (535 and 556 respectively in this structure).

Details

Redox score ?
83
PDB code
7nxd
Structure name
cryo-em structure of human integrin alpha5beta1 in the half-bent conformation
Structure deposition date
2021-03-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide accession
P05556
Residue number A
555
Residue number B
576
Peptide name
Integrin beta-1

Ligandability

Cysteine 555 of Integrin beta-1

Cysteine 576 of Integrin beta-1

A redox-regulated disulphide may form within Integrin beta-1 between cysteines 38 and 64 (18 and 44 respectively in this structure).

Details

Redox score ?
82
PDB code
4wk4
Structure name
metal ion and ligand binding of integrin
Structure deposition date
2014-10-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide accession
P05556
Residue number A
38
Residue number B
64
Peptide name
Integrin beta-1

Ligandability

Cysteine 38 of Integrin beta-1

Cysteine 64 of Integrin beta-1

A redox-regulated disulphide may form within Integrin beta-1 between cysteines 592 and 615 (572 and 595 respectively in this structure).

Details

Redox score ?
82
PDB code
7nxd
Structure name
cryo-em structure of human integrin alpha5beta1 in the half-bent conformation
Structure deposition date
2021-03-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
P05556
Residue number A
592
Residue number B
615
Peptide name
Integrin beta-1

Ligandability

Cysteine 592 of Integrin beta-1

Cysteine 615 of Integrin beta-1

A redox-regulated disulphide may form within Integrin beta-1 between cysteines 486 and 261 (420 and 440 respectively in this structure).

Details

Redox score ?
81
PDB code
3t9k
Structure name
crystal structure of acap1 c-portion mutant s554d fused with integrin beta1 peptide
Structure deposition date
2011-08-03
Thiol separation (Å)
4
Half-sphere exposure sum ?
71
Minimum pKa ?
4
% buried
78
Peptide accession
P05556
Residue number A
486
Residue number B
261
Peptide name
Integrin beta-1

Ligandability

Cysteine 486 of Integrin beta-1

Cysteine 261 of Integrin beta-1

A redox-regulated disulphide may form within Integrin beta-1 between cysteines 599 and 618 (579 and 598 respectively in this structure).

Details

Redox score ?
80
PDB code
7nxd
Structure name
cryo-em structure of human integrin alpha5beta1 in the half-bent conformation
Structure deposition date
2021-03-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
P05556
Residue number A
599
Residue number B
618
Peptide name
Integrin beta-1

Ligandability

Cysteine 599 of Integrin beta-1

Cysteine 618 of Integrin beta-1

A redox-regulated disulphide may form within Integrin beta-1 between cysteines 568 and 574 (548 and 554 respectively in this structure).

Details

Redox score ?
79
PDB code
7nxd
Structure name
cryo-em structure of human integrin alpha5beta1 in the half-bent conformation
Structure deposition date
2021-03-18
Thiol separation (Å)
3
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
P05556
Residue number A
568
Residue number B
574
Peptide name
Integrin beta-1

Ligandability

Cysteine 568 of Integrin beta-1

Cysteine 574 of Integrin beta-1

A redox-regulated disulphide may form within Integrin beta-1 between cysteines 599 and 607 (579 and 587 respectively in this structure).

Details

Redox score ?
75
PDB code
7nxd
Structure name
cryo-em structure of human integrin alpha5beta1 in the half-bent conformation
Structure deposition date
2021-03-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
P05556
Residue number A
599
Residue number B
607
Peptide name
Integrin beta-1

Ligandability

Cysteine 599 of Integrin beta-1

Cysteine 607 of Integrin beta-1

A redox-regulated disulphide may form within Integrin beta-1 between cysteines 516 and 536 (496 and 516 respectively in this structure).

Details

Redox score ?
75
PDB code
7nxd
Structure name
cryo-em structure of human integrin alpha5beta1 in the half-bent conformation
Structure deposition date
2021-03-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
P05556
Residue number A
516
Residue number B
536
Peptide name
Integrin beta-1

Ligandability

Cysteine 516 of Integrin beta-1

Cysteine 536 of Integrin beta-1

A redox-regulated disulphide may form within Integrin beta-1 between cysteines 516 and 525 (496 and 505 respectively in this structure).

Details

Redox score ?
74
PDB code
7nxd
Structure name
cryo-em structure of human integrin alpha5beta1 in the half-bent conformation
Structure deposition date
2021-03-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
P05556
Residue number A
516
Residue number B
525
Peptide name
Integrin beta-1

Ligandability

Cysteine 516 of Integrin beta-1

Cysteine 525 of Integrin beta-1

A redox-regulated disulphide may form within Integrin beta-1 between cysteines 560 and 568 (540 and 548 respectively in this structure).

Details

Redox score ?
73
PDB code
7nxd
Structure name
cryo-em structure of human integrin alpha5beta1 in the half-bent conformation
Structure deposition date
2021-03-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
P05556
Residue number A
560
Residue number B
568
Peptide name
Integrin beta-1

Ligandability

Cysteine 560 of Integrin beta-1

Cysteine 568 of Integrin beta-1

A redox-regulated disulphide may form within Integrin beta-1 between cysteines 574 and 579 (554 and 559 respectively in this structure).

Details

Redox score ?
73
PDB code
7nxd
Structure name
cryo-em structure of human integrin alpha5beta1 in the half-bent conformation
Structure deposition date
2021-03-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
P05556
Residue number A
574
Residue number B
579
Peptide name
Integrin beta-1

Ligandability

Cysteine 574 of Integrin beta-1

Cysteine 579 of Integrin beta-1

A redox-regulated disulphide may form within Integrin beta-1 between cysteines 613 and 618 (593 and 598 respectively in this structure).

Details

Redox score ?
72
PDB code
7nxd
Structure name
cryo-em structure of human integrin alpha5beta1 in the half-bent conformation
Structure deposition date
2021-03-18
Thiol separation (Å)
5
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
P05556
Residue number A
613
Residue number B
618
Peptide name
Integrin beta-1

Ligandability

Cysteine 613 of Integrin beta-1

Cysteine 618 of Integrin beta-1

A redox-regulated disulphide may form within Integrin beta-1 between cysteines 560 and 579 (540 and 559 respectively in this structure).

Details

Redox score ?
71
PDB code
7nxd
Structure name
cryo-em structure of human integrin alpha5beta1 in the half-bent conformation
Structure deposition date
2021-03-18
Thiol separation (Å)
5
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
P05556
Residue number A
560
Residue number B
579
Peptide name
Integrin beta-1

Ligandability

Cysteine 560 of Integrin beta-1

Cysteine 579 of Integrin beta-1

A redox-regulated disulphide may form within Integrin beta-1 between cysteines 607 and 613 (587 and 593 respectively in this structure).

Details

Redox score ?
71
PDB code
7nxd
Structure name
cryo-em structure of human integrin alpha5beta1 in the half-bent conformation
Structure deposition date
2021-03-18
Thiol separation (Å)
5
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
P05556
Residue number A
607
Residue number B
613
Peptide name
Integrin beta-1

Ligandability

Cysteine 607 of Integrin beta-1

Cysteine 613 of Integrin beta-1

A redox-regulated disulphide may form within Integrin beta-1 between cysteines 525 and 531 (505 and 511 respectively in this structure).

Details

Redox score ?
70
PDB code
7nxd
Structure name
cryo-em structure of human integrin alpha5beta1 in the half-bent conformation
Structure deposition date
2021-03-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
P05556
Residue number A
525
Residue number B
531
Peptide name
Integrin beta-1

Ligandability

Cysteine 525 of Integrin beta-1

Cysteine 531 of Integrin beta-1

A redox-regulated disulphide may form within Integrin beta-1 between cysteines 489 and 500 (469 and 480 respectively in this structure).

Details

Redox score ?
69
PDB code
7nxd
Structure name
cryo-em structure of human integrin alpha5beta1 in the half-bent conformation
Structure deposition date
2021-03-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
P05556
Residue number A
489
Residue number B
500
Peptide name
Integrin beta-1

Ligandability

Cysteine 489 of Integrin beta-1

Cysteine 500 of Integrin beta-1

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