ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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T-cell surface glycoprotein CD1a

Intramolecular
Cysteine 223 and cysteine 278
Cysteine 119 and cysteine 183
A redox-regulated disulphide may form within T-cell surface glycoprotein CD1a between cysteines 223 and 278 (206 and 261 respectively in this structure).

Details

Redox score ?
80
PDB code
7kp1
Structure name
cd1a-42:2 sm binary complex
Structure deposition date
2020-11-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
P06126
Residue number A
223
Residue number B
278
Peptide name
T-cell surface glycoprotein CD1a

Ligandability

Cysteine 223 of T-cell surface glycoprotein CD1a

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 278 of T-cell surface glycoprotein CD1a

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within T-cell surface glycoprotein CD1a between cysteines 119 and 183 (102 and 166 respectively in this structure).

Details

Redox score ?
74
PDB code
1onq
Structure name
crystal structure of cd1a in complex with a sulfatide
Structure deposition date
2003-02-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
70
Minimum pKa ?
8
% buried
88
Peptide accession
P06126
Residue number A
119
Residue number B
183
Peptide name
T-cell surface glycoprotein CD1a

Ligandability

Cysteine 119 of T-cell surface glycoprotein CD1a

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 183 of T-cell surface glycoprotein CD1a

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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