ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Uroporphyrinogen decarboxylase

Intramolecular
Cysteine 59 and cysteine 65 L
Cysteine 65 and cysteine 66 L
A redox-regulated disulphide may form within Uroporphyrinogen decarboxylase between cysteines 59 and 65.

Details

Redox score ?
68
PDB code
1jpk
Structure name
gly156asp mutant of human urod, human uroporphyrinogen iii decarboxylase
Structure deposition date
2001-08-02
Thiol separation (Å)
4
Half-sphere exposure sum ?
73
Minimum pKa ?
9
% buried
84
Peptide accession
P06132
Residue number A
59
Residue number B
65
Peptide name
Uroporphyrinogen decarboxylase

Ligandability

Cysteine 59 of Uroporphyrinogen decarboxylase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 65 of Uroporphyrinogen decarboxylase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Uroporphyrinogen decarboxylase between cysteines 65 and 66. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
3gvw
Structure name
single-chain urod f217y (yf) mutation
Structure deposition date
2009-03-31
Thiol separation (Å)
9
Half-sphere exposure sum ?
77
Minimum pKa ?
10
% buried
67
Peptide accession
P06132
Residue number A
65
Residue number B
66
Peptide name
Uroporphyrinogen decarboxylase

Ligandability

Cysteine 65 of Uroporphyrinogen decarboxylase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 66 of Uroporphyrinogen decarboxylase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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