Insulin receptor
Intermolecular
Cysteine 710 and cysteine 710
Cysteine 551 and cysteine 551
Cysteine 544 of Insulin-like growth factor 1 receptor and cysteine 551
Cysteine 674 and cysteine 887
Cysteine 712 and cysteine 710
Intramolecular
Cysteine 331 and cysteine 335
Cysteine 293 and cysteine 301
Cysteine 268 and cysteine 280
Cysteine 235 and cysteine 243
Cysteine 315 and cysteine 328
More...Cysteine 223 and cysteine 234
Cysteine 286 and cysteine 311
Cysteine 239 and cysteine 252
Cysteine 35 and cysteine 53
Cysteine 813 and cysteine 822
Cysteine 153 and cysteine 182
Cysteine 339 and cysteine 360
Cysteine 674 and cysteine 887
Cysteine 255 and cysteine 264
Cysteine 462 and cysteine 495
Cysteine 219 and cysteine 228
Cysteine 186 and cysteine 209
Cysteine 186 and cysteine 196
Cysteine 252 and cysteine 264
Cysteine 219 and cysteine 223
Cysteine 223 and cysteine 228
Cysteine 196 and cysteine 215
Cysteine 196 and cysteine 209
Cysteine 239 and cysteine 243
Cysteine 196 and cysteine 209
Cysteine 235 and cysteine 239
Cysteine 252 and cysteine 255
Cysteine 223 and cysteine 235
Cysteine 239 and cysteine 264
Cysteine 551 and cysteine 712
Cysteine 219 and cysteine 235
Cysteine 186 and cysteine 215
Cysteine 243 and cysteine 252
Cysteine 709 and cysteine 710
Cysteine 235 and cysteine 252
6sof A 683 C 683
A redox-regulated disulphide may form between two units of Insulin receptor at cysteines 710 and 710 (683 and 683 respectively in this structure).
Details
Redox score ?
86
PDB code
6sof
Structure name
human insulin receptor ectodomain bound by 4 insulin
Structure deposition date
2019-08-29
Thiol separation (Å)
2
Half-sphere exposure sum ?
43
Minimum pKa ?
nan
% buried
nan
Peptide A name
Insulin receptor
Peptide B name
Insulin receptor
Peptide A accession
P06213
Peptide B accession
P06213
Peptide A residue number
710
Peptide B residue number
710
Ligandability
5kqv E 524 F 524
A redox-regulated disulphide may form between two units of Insulin receptor at cysteines 551 and 551 (524 and 524 respectively in this structure).
Details
Redox score ?
84
PDB code
5kqv
Structure name
insulin receptor ectodomain construct comprising domains l1,cr,l2, fniii-1 and alphact peptide in complex with bovine insulin and fab 83-14 (revised structure)
Structure deposition date
2016-07-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide A name
Insulin receptor
Peptide B name
Insulin receptor
Peptide A accession
P06213
Peptide B accession
P06213
Peptide A residue number
551
Peptide B residue number
551
Ligandability
7s0q A 514 B 524
A redox-regulated disulphide may form between cysteine 544 of Insulin-like growth factor 1 receptor and cysteine 551 of Insulin receptor (514 and 524 respectively in this structure).
Details
Redox score ?
83
PDB code
7s0q
Structure name
head region of a complex of igf-i with the ectodomain of a hybrid insulin receptor / type 1 insulin-like growth factor receptor
Structure deposition date
2021-08-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide A name
Insulin-like growth factor 1 receptor
Peptide B name
Insulin receptor
Peptide A accession
P08069
Peptide B accession
P06213
Peptide A residue number
544
Peptide B residue number
551
Ligandability
Cysteine 544 of Insulin-like growth factor 1 receptor
Cysteine 551 of Insulin receptor
7qid A 647 B 860
A redox-regulated disulphide may form between cysteine 674 of Insulin receptor and cysteine 887 of Isoform Short of Insulin receptor (647 and 860 respectively in this structure).
Details
Redox score ?
81
PDB code
7qid
Structure name
tentative model of the human insulin receptor ectodomain bound by three insulin
Structure deposition date
2021-12-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide A name
Insulin receptor
Peptide B name
Isoform Short of Insulin receptor
Peptide A accession
P06213
Peptide B accession
P06213-2
Peptide A residue number
674
Peptide B residue number
887
Ligandability
Cysteine 674 of Insulin receptor
Cysteine 887 of Isoform Short of Insulin receptor
7yq3 E 685 F 683
A redox-regulated disulphide may form between two units of Insulin receptor at cysteines 712 and 710 (685 and 683 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
58
PDB code
7yq3
Structure name
human insulin receptor bound with a43 dna aptamer and insulin
Structure deposition date
2022-08-05
Thiol separation (Å)
8
Half-sphere exposure sum ?
nan
Minimum pKa ?
9
% buried
nan
Peptide A name
Insulin receptor
Peptide B name
Insulin receptor
Peptide A accession
P06213
Peptide B accession
P06213
Peptide A residue number
712
Peptide B residue number
710
Ligandability
Cysteine 712 of Insulin receptor
Cysteine 710 of Insulin receptor
7mqs F 304 F 308
A redox-regulated disulphide may form within Isoform Short of Insulin receptor between cysteines 331 and 335 (304 and 308 respectively in this structure).
Details
Redox score ?
89
PDB code
7mqs
Structure name
the insulin receptor ectodomain in complex with three venom hybrid insulin molecules - asymmetric conformation
Structure deposition date
2021-05-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
36
Minimum pKa ?
nan
% buried
nan
Peptide accession
P06213-2
Residue number A
331
Residue number B
335
Peptide name
Isoform Short of Insulin receptor
Ligandability
Cysteine 331 of Isoform Short of Insulin receptor
Cysteine 335 of Isoform Short of Insulin receptor
2hr7 B 266 B 274
A redox-regulated disulphide may form within Insulin receptor between cysteines 293 and 301 (266 and 274 respectively in this structure).
Details
Redox score ?
88
PDB code
2hr7
Structure name
insulin receptor (domains 1-3)
Structure deposition date
2006-07-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
36
Minimum pKa ?
nan
% buried
nan
Peptide accession
P06213
Residue number A
293
Residue number B
301
Peptide name
Insulin receptor
Ligandability
Cysteine 293 of Insulin receptor
Cysteine 301 of Insulin receptor
7mqs E 241 E 253
A redox-regulated disulphide may form within Isoform Short of Insulin receptor between cysteines 268 and 280 (241 and 253 respectively in this structure).
Details
Redox score ?
88
PDB code
7mqs
Structure name
the insulin receptor ectodomain in complex with three venom hybrid insulin molecules - asymmetric conformation
Structure deposition date
2021-05-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
P06213-2
Residue number A
268
Residue number B
280
Peptide name
Isoform Short of Insulin receptor
Ligandability
Cysteine 268 of Isoform Short of Insulin receptor
Cysteine 280 of Isoform Short of Insulin receptor
7mqs E 208 E 216
A redox-regulated disulphide may form within Isoform Short of Insulin receptor between cysteines 235 and 243 (208 and 216 respectively in this structure).
Details
Redox score ?
87
PDB code
7mqs
Structure name
the insulin receptor ectodomain in complex with three venom hybrid insulin molecules - asymmetric conformation
Structure deposition date
2021-05-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
P06213-2
Residue number A
235
Residue number B
243
Peptide name
Isoform Short of Insulin receptor
Ligandability
Cysteine 235 of Isoform Short of Insulin receptor
Cysteine 243 of Isoform Short of Insulin receptor
7u6e E 288 E 301
A redox-regulated disulphide may form within Isoform Short of Insulin receptor between cysteines 315 and 328 (288 and 301 respectively in this structure).
Details
Redox score ?
86
PDB code
7u6e
Structure name
head region of insulin receptor ectodomain (a-isoform) bound to the non-insulin agonist im462
Structure deposition date
2022-03-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
P06213-2
Residue number A
315
Residue number B
328
Peptide name
Isoform Short of Insulin receptor
Ligandability
Cysteine 315 of Isoform Short of Insulin receptor
Cysteine 328 of Isoform Short of Insulin receptor
7mqs E 196 E 207
A redox-regulated disulphide may form within Isoform Short of Insulin receptor between cysteines 223 and 234 (196 and 207 respectively in this structure).
Details
Redox score ?
85
PDB code
7mqs
Structure name
the insulin receptor ectodomain in complex with three venom hybrid insulin molecules - asymmetric conformation
Structure deposition date
2021-05-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
P06213-2
Residue number A
223
Residue number B
234
Peptide name
Isoform Short of Insulin receptor
Ligandability
Cysteine 223 of Isoform Short of Insulin receptor
Cysteine 234 of Isoform Short of Insulin receptor
6vep K 259 K 284
A redox-regulated disulphide may form within Insulin receptor between cysteines 286 and 311 (259 and 284 respectively in this structure).
Details
Redox score ?
85
PDB code
6vep
Structure name
human insulin in complex with the human insulin microreceptor in turn in complex with fv 83-7
Structure deposition date
2020-01-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
P06213
Residue number A
286
Residue number B
311
Peptide name
Insulin receptor
Ligandability
Cysteine 286 of Insulin receptor
Cysteine 311 of Insulin receptor
7mqs E 212 E 225
A redox-regulated disulphide may form within Isoform Short of Insulin receptor between cysteines 239 and 252 (212 and 225 respectively in this structure).
Details
Redox score ?
84
PDB code
7mqs
Structure name
the insulin receptor ectodomain in complex with three venom hybrid insulin molecules - asymmetric conformation
Structure deposition date
2021-05-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
P06213-2
Residue number A
239
Residue number B
252
Peptide name
Isoform Short of Insulin receptor
Ligandability
Cysteine 239 of Isoform Short of Insulin receptor
Cysteine 252 of Isoform Short of Insulin receptor
7u6e E 8 E 26
A redox-regulated disulphide may form within Isoform Short of Insulin receptor between cysteines 35 and 53 (8 and 26 respectively in this structure).
Details
Redox score ?
84
PDB code
7u6e
Structure name
head region of insulin receptor ectodomain (a-isoform) bound to the non-insulin agonist im462
Structure deposition date
2022-03-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
P06213-2
Residue number A
35
Residue number B
53
Peptide name
Isoform Short of Insulin receptor
Ligandability
Cysteine 35 of Isoform Short of Insulin receptor
Cysteine 53 of Isoform Short of Insulin receptor
7qid B 786 B 795
A redox-regulated disulphide may form within Isoform Short of Insulin receptor between cysteines 813 and 822 (786 and 795 respectively in this structure).
Details
Redox score ?
84
PDB code
7qid
Structure name
tentative model of the human insulin receptor ectodomain bound by three insulin
Structure deposition date
2021-12-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
P06213-2
Residue number A
813
Residue number B
822
Peptide name
Isoform Short of Insulin receptor
Ligandability
Cysteine 813 of Isoform Short of Insulin receptor
Cysteine 822 of Isoform Short of Insulin receptor
7mqs F 126 F 155
A redox-regulated disulphide may form within Isoform Short of Insulin receptor between cysteines 153 and 182 (126 and 155 respectively in this structure).
Details
Redox score ?
83
PDB code
7mqs
Structure name
the insulin receptor ectodomain in complex with three venom hybrid insulin molecules - asymmetric conformation
Structure deposition date
2021-05-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
P06213-2
Residue number A
153
Residue number B
182
Peptide name
Isoform Short of Insulin receptor
Ligandability
Cysteine 153 of Isoform Short of Insulin receptor
Cysteine 182 of Isoform Short of Insulin receptor
2hr7 A 312 A 333
A redox-regulated disulphide may form within Insulin receptor between cysteines 339 and 360 (312 and 333 respectively in this structure).
Details
Redox score ?
83
PDB code
2hr7
Structure name
insulin receptor (domains 1-3)
Structure deposition date
2006-07-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
P06213
Residue number A
339
Residue number B
360
Peptide name
Insulin receptor
Ligandability
Cysteine 339 of Insulin receptor
Cysteine 360 of Insulin receptor
7mqs E 647 E 860
A redox-regulated disulphide may form within Isoform Short of Insulin receptor between cysteines 674 and 887 (647 and 860 respectively in this structure).
Details
Redox score ?
82
PDB code
7mqs
Structure name
the insulin receptor ectodomain in complex with three venom hybrid insulin molecules - asymmetric conformation
Structure deposition date
2021-05-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
P06213-2
Residue number A
674
Residue number B
887
Peptide name
Isoform Short of Insulin receptor
Ligandability
Cysteine 674 of Isoform Short of Insulin receptor
Cysteine 887 of Isoform Short of Insulin receptor
7mqs F 228 F 237
A redox-regulated disulphide may form within Isoform Short of Insulin receptor between cysteines 255 and 264 (228 and 237 respectively in this structure).
Details
Redox score ?
82
PDB code
7mqs
Structure name
the insulin receptor ectodomain in complex with three venom hybrid insulin molecules - asymmetric conformation
Structure deposition date
2021-05-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
P06213-2
Residue number A
255
Residue number B
264
Peptide name
Isoform Short of Insulin receptor
Ligandability
Cysteine 255 of Isoform Short of Insulin receptor
Cysteine 264 of Isoform Short of Insulin receptor
7mqs E 435 E 468
A redox-regulated disulphide may form within Isoform Short of Insulin receptor between cysteines 462 and 495 (435 and 468 respectively in this structure).
Details
Redox score ?
81
PDB code
7mqs
Structure name
the insulin receptor ectodomain in complex with three venom hybrid insulin molecules - asymmetric conformation
Structure deposition date
2021-05-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
P06213-2
Residue number A
462
Residue number B
495
Peptide name
Isoform Short of Insulin receptor
Ligandability
Cysteine 462 of Isoform Short of Insulin receptor
Cysteine 495 of Isoform Short of Insulin receptor
7mqs E 192 E 201
A redox-regulated disulphide may form within Isoform Short of Insulin receptor between cysteines 219 and 228 (192 and 201 respectively in this structure).
Details
Redox score ?
79
PDB code
7mqs
Structure name
the insulin receptor ectodomain in complex with three venom hybrid insulin molecules - asymmetric conformation
Structure deposition date
2021-05-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
P06213-2
Residue number A
219
Residue number B
228
Peptide name
Isoform Short of Insulin receptor
Ligandability
Cysteine 219 of Isoform Short of Insulin receptor
Cysteine 228 of Isoform Short of Insulin receptor
7md5 A 159 A 182
A redox-regulated disulphide may form within Insulin receptor between cysteines 186 and 209 (159 and 182 respectively in this structure).
Details
Redox score ?
77
PDB code
7md5
Structure name
insulin receptor ectodomain dimer complexed with two irpa-9 partial agonists
Structure deposition date
2021-04-03
Thiol separation (Å)
4
Half-sphere exposure sum ?
58
Minimum pKa ?
10
% buried
26
Peptide accession
P06213
Residue number A
186
Residue number B
209
Peptide name
Insulin receptor
Ligandability
Cysteine 186 of Insulin receptor
Cysteine 209 of Insulin receptor
7mqs E 159 E 169
A redox-regulated disulphide may form within Isoform Short of Insulin receptor between cysteines 186 and 196 (159 and 169 respectively in this structure).
Details
Redox score ?
77
PDB code
7mqs
Structure name
the insulin receptor ectodomain in complex with three venom hybrid insulin molecules - asymmetric conformation
Structure deposition date
2021-05-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
P06213-2
Residue number A
186
Residue number B
196
Peptide name
Isoform Short of Insulin receptor
Ligandability
Cysteine 186 of Isoform Short of Insulin receptor
Cysteine 196 of Isoform Short of Insulin receptor
3w11 E 225 E 237
A redox-regulated disulphide may form within Insulin receptor between cysteines 252 and 264 (225 and 237 respectively in this structure).
Details
Redox score ?
77
PDB code
3w11
Structure name
insulin receptor ectodomain construct comprising domains l1-cr in complex with human insulin, alpha-ct peptide(704-719) and fab 83-7
Structure deposition date
2012-11-06
Thiol separation (Å)
3
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
P06213
Residue number A
252
Residue number B
264
Peptide name
Insulin receptor
Ligandability
Cysteine 252 of Insulin receptor
Cysteine 264 of Insulin receptor
3w13 E 192 E 196
A redox-regulated disulphide may form within Insulin receptor between cysteines 219 and 223 (192 and 196 respectively in this structure).
Details
Redox score ?
72
PDB code
3w13
Structure name
insulin receptor ectodomain construct comprising domains l1-cr in complex with high-affinity insulin analogue [d-pro-b26]-dti-nh2, alphact peptide(693-719) and fab 83-7
Structure deposition date
2012-11-06
Thiol separation (Å)
5
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
P06213
Residue number A
219
Residue number B
223
Peptide name
Insulin receptor
Ligandability
Cysteine 219 of Insulin receptor
Cysteine 223 of Insulin receptor
2hr7 A 196 A 201
A redox-regulated disulphide may form within Insulin receptor between cysteines 223 and 228 (196 and 201 respectively in this structure).
Details
Redox score ?
70
PDB code
2hr7
Structure name
insulin receptor (domains 1-3)
Structure deposition date
2006-07-19
Thiol separation (Å)
5
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
P06213
Residue number A
223
Residue number B
228
Peptide name
Insulin receptor
Ligandability
Cysteine 223 of Insulin receptor
Cysteine 228 of Insulin receptor
6sof C 169 C 188
A redox-regulated disulphide may form within Insulin receptor between cysteines 196 and 215 (169 and 188 respectively in this structure).
Details
Redox score ?
67
PDB code
6sof
Structure name
human insulin receptor ectodomain bound by 4 insulin
Structure deposition date
2019-08-29
Thiol separation (Å)
6
Half-sphere exposure sum ?
62
Minimum pKa ?
9
% buried
20
Peptide accession
P06213
Residue number A
196
Residue number B
215
Peptide name
Insulin receptor
Ligandability
Cysteine 196 of Insulin receptor
Cysteine 215 of Insulin receptor
8dtm A 169 A 182
A redox-regulated disulphide may form within Insulin receptor between cysteines 196 and 209 (169 and 182 respectively in this structure).
Details
Redox score ?
67
PDB code
8dtm
Structure name
cryo-em structure of insulin receptor (ir) bound with s597 component 2
Structure deposition date
2022-07-26
Thiol separation (Å)
5
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P15208
Residue number A
196
Residue number B
209
Peptide name
Insulin receptor
Ligandability
Cysteine 196 of Insulin receptor
Cysteine 209 of Insulin receptor
6vep W 212 W 216
A redox-regulated disulphide may form within Insulin receptor between cysteines 239 and 243 (212 and 216 respectively in this structure).
Details
Redox score ?
66
PDB code
6vep
Structure name
human insulin in complex with the human insulin microreceptor in turn in complex with fv 83-7
Structure deposition date
2020-01-02
Thiol separation (Å)
5
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
P06213
Residue number A
239
Residue number B
243
Peptide name
Insulin receptor
Ligandability
Cysteine 239 of Insulin receptor
Cysteine 243 of Insulin receptor
2hr7 B 169 B 182
A redox-regulated disulphide may form within Insulin receptor between cysteines 196 and 209 (169 and 182 respectively in this structure).
Details
Redox score ?
65
PDB code
2hr7
Structure name
insulin receptor (domains 1-3)
Structure deposition date
2006-07-19
Thiol separation (Å)
5
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
P06213
Residue number A
196
Residue number B
209
Peptide name
Insulin receptor
Ligandability
Cysteine 196 of Insulin receptor
Cysteine 209 of Insulin receptor
7mqs F 208 F 212
A redox-regulated disulphide may form within Isoform Short of Insulin receptor between cysteines 235 and 239 (208 and 212 respectively in this structure).
Details
Redox score ?
65
PDB code
7mqs
Structure name
the insulin receptor ectodomain in complex with three venom hybrid insulin molecules - asymmetric conformation
Structure deposition date
2021-05-06
Thiol separation (Å)
5
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
P06213-2
Residue number A
235
Residue number B
239
Peptide name
Isoform Short of Insulin receptor
Ligandability
Cysteine 235 of Isoform Short of Insulin receptor
Cysteine 239 of Isoform Short of Insulin receptor
3w11 E 225 E 228
A redox-regulated disulphide may form within Insulin receptor between cysteines 252 and 255 (225 and 228 respectively in this structure).
Details
Redox score ?
64
PDB code
3w11
Structure name
insulin receptor ectodomain construct comprising domains l1-cr in complex with human insulin, alpha-ct peptide(704-719) and fab 83-7
Structure deposition date
2012-11-06
Thiol separation (Å)
5
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
P06213
Residue number A
252
Residue number B
255
Peptide name
Insulin receptor
Ligandability
Cysteine 252 of Insulin receptor
Cysteine 255 of Insulin receptor
7mqs F 196 F 208
A redox-regulated disulphide may form within Isoform Short of Insulin receptor between cysteines 223 and 235 (196 and 208 respectively in this structure).
Details
Redox score ?
63
PDB code
7mqs
Structure name
the insulin receptor ectodomain in complex with three venom hybrid insulin molecules - asymmetric conformation
Structure deposition date
2021-05-06
Thiol separation (Å)
6
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
P06213-2
Residue number A
223
Residue number B
235
Peptide name
Isoform Short of Insulin receptor
Ligandability
Cysteine 223 of Isoform Short of Insulin receptor
Cysteine 235 of Isoform Short of Insulin receptor
3w13 E 212 E 237
A redox-regulated disulphide may form within Insulin receptor between cysteines 239 and 264 (212 and 237 respectively in this structure).
Details
Redox score ?
63
PDB code
3w13
Structure name
insulin receptor ectodomain construct comprising domains l1-cr in complex with high-affinity insulin analogue [d-pro-b26]-dti-nh2, alphact peptide(693-719) and fab 83-7
Structure deposition date
2012-11-06
Thiol separation (Å)
5
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
P06213
Residue number A
239
Residue number B
264
Peptide name
Insulin receptor
Ligandability
Cysteine 239 of Insulin receptor
Cysteine 264 of Insulin receptor
7pg4 B 524 B 685
A redox-regulated disulphide may form within Insulin receptor between cysteines 551 and 712 (524 and 685 respectively in this structure).
Details
Redox score ?
60
PDB code
7pg4
Structure name
low resolution cryo-em structure of the full-length insulin receptor bound to 2 insulin, conf 3
Structure deposition date
2021-08-12
Thiol separation (Å)
6
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
P06213
Residue number A
551
Residue number B
712
Peptide name
Insulin receptor
Ligandability
Cysteine 551 of Insulin receptor
Cysteine 712 of Insulin receptor
6vep Q 192 Q 208
A redox-regulated disulphide may form within Insulin receptor between cysteines 219 and 235 (192 and 208 respectively in this structure).
Details
Redox score ?
60
PDB code
6vep
Structure name
human insulin in complex with the human insulin microreceptor in turn in complex with fv 83-7
Structure deposition date
2020-01-02
Thiol separation (Å)
7
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
P06213
Residue number A
219
Residue number B
235
Peptide name
Insulin receptor
Ligandability
Cysteine 219 of Insulin receptor
Cysteine 235 of Insulin receptor
6vep W 159 W 188
A redox-regulated disulphide may form within Insulin receptor between cysteines 186 and 215 (159 and 188 respectively in this structure).
Details
Redox score ?
60
PDB code
6vep
Structure name
human insulin in complex with the human insulin microreceptor in turn in complex with fv 83-7
Structure deposition date
2020-01-02
Thiol separation (Å)
6
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
P06213
Residue number A
186
Residue number B
215
Peptide name
Insulin receptor
Ligandability
Cysteine 186 of Insulin receptor
Cysteine 215 of Insulin receptor
7kd6 W 216 W 225
A redox-regulated disulphide may form within Insulin receptor between cysteines 243 and 252 (216 and 225 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
59
PDB code
7kd6
Structure name
insulin receptor l1-cr plus alphact fragment in co-complex with fv 83- 7 and single-chain insulin sci-b
Structure deposition date
2020-10-08
Thiol separation (Å)
7
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
P06213
Residue number A
243
Residue number B
252
Peptide name
Insulin receptor
Ligandability
Cysteine 243 of Insulin receptor
Cysteine 252 of Insulin receptor
6sof C 682 C 683
A redox-regulated disulphide may form within Insulin receptor between cysteines 709 and 710 (682 and 683 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
59
PDB code
6sof
Structure name
human insulin receptor ectodomain bound by 4 insulin
Structure deposition date
2019-08-29
Thiol separation (Å)
7
Half-sphere exposure sum ?
44
Minimum pKa ?
nan
% buried
nan
Peptide accession
P06213
Residue number A
709
Residue number B
710
Peptide name
Insulin receptor
Ligandability
Cysteine 709 of Insulin receptor
Cysteine 710 of Insulin receptor
7kd6 E 208 E 225
A redox-regulated disulphide may form within Insulin receptor between cysteines 235 and 252 (208 and 225 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
58
PDB code
7kd6
Structure name
insulin receptor l1-cr plus alphact fragment in co-complex with fv 83- 7 and single-chain insulin sci-b
Structure deposition date
2020-10-08
Thiol separation (Å)
7
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
P06213
Residue number A
235
Residue number B
252
Peptide name
Insulin receptor
Ligandability
Cysteine 235 of Insulin receptor
Cysteine 252 of Insulin receptor
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