Tyrosine-protein kinase Lck
Intermolecular
Cysteine 447 of T-cell surface glycoprotein CD4 and cysteine 20
Cysteine 445 of T-cell surface glycoprotein CD4 and cysteine 20
Cysteine 217 of T-cell surface glycoprotein CD8 alpha chain and cysteine 23
Cysteine 215 of T-cell surface glycoprotein CD8 alpha chain and cysteine 23
Cysteine 217 of T-cell surface glycoprotein CD8 alpha chain and cysteine 20
Cysteine 215 of T-cell surface glycoprotein CD8 alpha chain and cysteine 20
Cysteine 447 of T-cell surface glycoprotein CD4 and cysteine 23
Cysteine 445 of T-cell surface glycoprotein CD4 and cysteine 23
Intramolecular
Cysteine 20 and cysteine 23
1q68 A 422 B 20
A redox-regulated disulphide may form between cysteine 447 of T-cell surface glycoprotein CD4 and cysteine 20 of Tyrosine-protein kinase Lck (422 and 20 respectively in this structure).
Details
Redox score ?
90
PDB code
1q68
Structure name
solution structure of t-cell surface glycoprotein cd4 and proto- oncogene tyrosine-protein kinase lck fragments
Structure deposition date
2003-08-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
35
Minimum pKa ?
6
% buried
0
Peptide A name
T-cell surface glycoprotein CD4
Peptide B name
Tyrosine-protein kinase Lck
Peptide A accession
P01730
Peptide B accession
P06239
Peptide A residue number
447
Peptide B residue number
20
Ligandability
Cysteine 447 of T-cell surface glycoprotein CD4
Cysteine 20 of Tyrosine-protein kinase Lck
1q68 A 420 B 20
A redox-regulated disulphide may form between cysteine 445 of T-cell surface glycoprotein CD4 and cysteine 20 of Tyrosine-protein kinase Lck (420 and 20 respectively in this structure).
Details
Redox score ?
89
PDB code
1q68
Structure name
solution structure of t-cell surface glycoprotein cd4 and proto- oncogene tyrosine-protein kinase lck fragments
Structure deposition date
2003-08-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
40
Minimum pKa ?
6
% buried
0
Peptide A name
T-cell surface glycoprotein CD4
Peptide B name
Tyrosine-protein kinase Lck
Peptide A accession
P01730
Peptide B accession
P06239
Peptide A residue number
445
Peptide B residue number
20
Ligandability
Cysteine 445 of T-cell surface glycoprotein CD4
Cysteine 20 of Tyrosine-protein kinase Lck
1q69 A 196 B 23
A redox-regulated disulphide may form between cysteine 217 of T-cell surface glycoprotein CD8 alpha chain and cysteine 23 of Tyrosine-protein kinase Lck (196 and 23 respectively in this structure).
Details
Redox score ?
89
PDB code
1q69
Structure name
solution structure of t-cell surface glycoprotein cd8 alpha chain and proto-oncogene tyrosine-protein kinase lck fragments
Structure deposition date
2003-08-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
34
Minimum pKa ?
6
% buried
0
Peptide A name
T-cell surface glycoprotein CD8 alpha chain
Peptide B name
Tyrosine-protein kinase Lck
Peptide A accession
P01732
Peptide B accession
P06239
Peptide A residue number
217
Peptide B residue number
23
Ligandability
Cysteine 217 of T-cell surface glycoprotein CD8 alpha chain
Cysteine 23 of Tyrosine-protein kinase Lck
1q69 A 194 B 23
A redox-regulated disulphide may form between cysteine 215 of T-cell surface glycoprotein CD8 alpha chain and cysteine 23 of Tyrosine-protein kinase Lck (194 and 23 respectively in this structure).
Details
Redox score ?
88
PDB code
1q69
Structure name
solution structure of t-cell surface glycoprotein cd8 alpha chain and proto-oncogene tyrosine-protein kinase lck fragments
Structure deposition date
2003-08-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
40
Minimum pKa ?
6
% buried
0
Peptide A name
T-cell surface glycoprotein CD8 alpha chain
Peptide B name
Tyrosine-protein kinase Lck
Peptide A accession
P01732
Peptide B accession
P06239
Peptide A residue number
215
Peptide B residue number
23
Ligandability
Cysteine 215 of T-cell surface glycoprotein CD8 alpha chain
Cysteine 23 of Tyrosine-protein kinase Lck
1q69 A 196 B 20
A redox-regulated disulphide may form between cysteine 217 of T-cell surface glycoprotein CD8 alpha chain and cysteine 20 of Tyrosine-protein kinase Lck (196 and 20 respectively in this structure).
Details
Redox score ?
86
PDB code
1q69
Structure name
solution structure of t-cell surface glycoprotein cd8 alpha chain and proto-oncogene tyrosine-protein kinase lck fragments
Structure deposition date
2003-08-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
38
Minimum pKa ?
8
% buried
0
Peptide A name
T-cell surface glycoprotein CD8 alpha chain
Peptide B name
Tyrosine-protein kinase Lck
Peptide A accession
P01732
Peptide B accession
P06239
Peptide A residue number
217
Peptide B residue number
20
Ligandability
Cysteine 217 of T-cell surface glycoprotein CD8 alpha chain
Cysteine 20 of Tyrosine-protein kinase Lck
1q69 A 194 B 20
A redox-regulated disulphide may form between cysteine 215 of T-cell surface glycoprotein CD8 alpha chain and cysteine 20 of Tyrosine-protein kinase Lck (194 and 20 respectively in this structure).
Details
Redox score ?
85
PDB code
1q69
Structure name
solution structure of t-cell surface glycoprotein cd8 alpha chain and proto-oncogene tyrosine-protein kinase lck fragments
Structure deposition date
2003-08-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
44
Minimum pKa ?
8
% buried
0
Peptide A name
T-cell surface glycoprotein CD8 alpha chain
Peptide B name
Tyrosine-protein kinase Lck
Peptide A accession
P01732
Peptide B accession
P06239
Peptide A residue number
215
Peptide B residue number
20
Ligandability
Cysteine 215 of T-cell surface glycoprotein CD8 alpha chain
Cysteine 20 of Tyrosine-protein kinase Lck
1q68 A 422 B 23
A redox-regulated disulphide may form between cysteine 447 of T-cell surface glycoprotein CD4 and cysteine 23 of Tyrosine-protein kinase Lck (422 and 23 respectively in this structure).
Details
Redox score ?
85
PDB code
1q68
Structure name
solution structure of t-cell surface glycoprotein cd4 and proto- oncogene tyrosine-protein kinase lck fragments
Structure deposition date
2003-08-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
32
Minimum pKa ?
8
% buried
0
Peptide A name
T-cell surface glycoprotein CD4
Peptide B name
Tyrosine-protein kinase Lck
Peptide A accession
P01730
Peptide B accession
P06239
Peptide A residue number
447
Peptide B residue number
23
Ligandability
Cysteine 447 of T-cell surface glycoprotein CD4
Cysteine 23 of Tyrosine-protein kinase Lck
1q68 A 420 B 23
A redox-regulated disulphide may form between cysteine 445 of T-cell surface glycoprotein CD4 and cysteine 23 of Tyrosine-protein kinase Lck (420 and 23 respectively in this structure).
Details
Redox score ?
85
PDB code
1q68
Structure name
solution structure of t-cell surface glycoprotein cd4 and proto- oncogene tyrosine-protein kinase lck fragments
Structure deposition date
2003-08-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
37
Minimum pKa ?
8
% buried
0
Peptide A name
T-cell surface glycoprotein CD4
Peptide B name
Tyrosine-protein kinase Lck
Peptide A accession
P01730
Peptide B accession
P06239
Peptide A residue number
445
Peptide B residue number
23
Ligandability
Cysteine 445 of T-cell surface glycoprotein CD4
Cysteine 23 of Tyrosine-protein kinase Lck
1q68 B 20 B 23
A redox-regulated disulphide may form within Tyrosine-protein kinase Lck between cysteines 20 and 23.
Details
Redox score ?
89
PDB code
1q68
Structure name
solution structure of t-cell surface glycoprotein cd4 and proto- oncogene tyrosine-protein kinase lck fragments
Structure deposition date
2003-08-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
31
Minimum pKa ?
6
% buried
0
Peptide accession
P06239
Residue number A
20
Residue number B
23
Peptide name
Tyrosine-protein kinase Lck
Ligandability
Cysteine 20 of Tyrosine-protein kinase Lck
Cysteine 23 of Tyrosine-protein kinase Lck
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