ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Tyrosine-protein kinase Fyn

Intramolecular
Cysteine 239 and cysteine 240
Cysteine 487 and cysteine 491
A redox-regulated disulphide may form within Tyrosine-protein kinase Fyn between cysteines 239 and 240 (103 and 104 respectively in this structure).

Details

Redox score ?
81
PDB code
4u17
Structure name
swapped dimer of the human fyn-sh2 domain
Structure deposition date
2014-07-15
Thiol separation (Å)
4
Half-sphere exposure sum ?
22
Minimum pKa ?
8
% buried
0
Peptide accession
P06241
Residue number A
239
Residue number B
240
Peptide name
Tyrosine-protein kinase Fyn

Ligandability

Cysteine 239 of Tyrosine-protein kinase Fyn

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 240 of Tyrosine-protein kinase Fyn

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tyrosine-protein kinase Fyn between cysteines 487 and 491 (227 and 231 respectively in this structure).

Details

Redox score ?
76
PDB code
2dq7
Structure name
crystal structure of fyn kinase domain complexed with staurosporine
Structure deposition date
2006-05-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
50
Minimum pKa ?
9
% buried
22
Peptide accession
P06241
Residue number A
487
Residue number B
491
Peptide name
Tyrosine-protein kinase Fyn

Ligandability

Cysteine 487 of Tyrosine-protein kinase Fyn

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 491 of Tyrosine-protein kinase Fyn

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: