a tool for identifying drug-targetable redox-active disulphides

Gelsolin

Intramolecular

Cysteine 215 and cysteine 228

A redox-regulated disulphide may form within Gelsolin between cysteines 215 and 228 (188 and 201 respectively in this structure).

Details

Redox score ?

74

PDB code

Structure name

domain swap dimer of the g167r variant of gelsolin second domain

Structure deposition date

2017-05-23

Thiol separation (Å)

3

Half-sphere exposure sum ?

81

Minimum pK_a ?

nan

% buried

34

Peptide accession

Residue number A

215

Residue number B

228

Peptide name

Gelsolin

Ligandability

Cysteine 215 of Gelsolin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 228 of Gelsolin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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