ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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T-cell surface antigen CD2

Intramolecular
Cysteine 139 and cysteine 203
Cysteine 146 and cysteine 186 L
A redox-regulated disulphide may form within T-cell surface antigen CD2 between cysteines 139 and 203 (115 and 179 respectively in this structure).

Details

Redox score ?
88
PDB code
1hnf
Structure name
crystal structure of the extracellular region of the human cell adhesion molecule cd2 at 2
Structure deposition date
1994-08-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
45
Minimum pKa ?
nan
% buried
nan
Peptide accession
P06729
Residue number A
139
Residue number B
203
Peptide name
T-cell surface antigen CD2

Ligandability

Cysteine 139 of T-cell surface antigen CD2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 203 of T-cell surface antigen CD2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within T-cell surface antigen CD2 between cysteines 146 and 186 (122 and 162 respectively in this structure).

Details

Redox score ?
83
PDB code
1hnf
Structure name
crystal structure of the extracellular region of the human cell adhesion molecule cd2 at 2
Structure deposition date
1994-08-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
P06729
Residue number A
146
Residue number B
186
Peptide name
T-cell surface antigen CD2

Ligandability

Cysteine 146 of T-cell surface antigen CD2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 186 of T-cell surface antigen CD2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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