Eukaryotic translation initiation factor 4E

Intramolecular

A redox-regulated disulphide may form within Eukaryotic translation initiation factor 4E between cysteines 150 and 170. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

2gpq

Structure name

cap-free structure of eif4e suggests basis for its allosteric regulation

Structure deposition date

2006-04-18

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

P06730

Residue number A

150

Residue number B

170

Peptide name

Eukaryotic translation initiation factor 4E

Ligandability

Cysteine 150 of Eukaryotic translation initiation factor 4E

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.