ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Creatine kinase M-type

Intramolecular
Cysteine 254 and cysteine 146
Cysteine 74 and cysteine 283
A redox-regulated disulphide may form within Creatine kinase M-type between cysteines 254 and 146 (141 and 146 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
1g0w
Structure name
crystal structure of bovine retinal creatine kinase
Structure deposition date
2000-10-09
Thiol separation (Å)
7
Half-sphere exposure sum ?
73
Minimum pKa ?
10
% buried
68
Peptide accession
Q9XSC6
Residue number A
254
Residue number B
146
Peptide name
Creatine kinase M-type

Ligandability

Cysteine 254 of Creatine kinase M-type

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 146 of Creatine kinase M-type

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Uncertain whether structure cysteine 141 has been assigned to correct residue.
A redox-regulated disulphide may form within Creatine kinase M-type between cysteines 74 and 283. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
2crk
Structure name
muscle creatine kinase
Structure deposition date
1998-09-28
Thiol separation (Å)
7
Half-sphere exposure sum ?
89
Minimum pKa ?
10
% buried
100
Peptide accession
P00563
Residue number A
74
Residue number B
283
Peptide name
Creatine kinase M-type

Ligandability

Cysteine 74 of Creatine kinase M-type

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 283 of Creatine kinase M-type

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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