ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Glucose-6-phosphate isomerase

Intramolecular
Cysteine 333 and cysteine 404
A redox-regulated disulphide may form within Glucose-6-phosphate isomerase between cysteines 333 and 404 (332 and 403 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
25
PDB code
1jlh
Structure name
human glucose-6-phosphate isomerase
Structure deposition date
2001-07-16
Thiol separation (Å)
10
Half-sphere exposure sum ?
73
Minimum pKa ?
13
% buried
98
Peptide accession
P06744
Residue number A
333
Residue number B
404
Peptide name
Glucose-6-phosphate isomerase

Ligandability

Cysteine 333 of Glucose-6-phosphate isomerase

Cysteine 404 of Glucose-6-phosphate isomerase

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