ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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L-lactate dehydrogenase B chain

Intramolecular
Cysteine 164 and cysteine 294
A redox-regulated disulphide may form within L-lactate dehydrogenase B chain between cysteines 164 and 294 (165 and 291 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
5ldh
Structure name
structure of the active ternary complex of pig heart lactate dehydrogenase with s-lac-nad at 2
Structure deposition date
1980-10-29
Thiol separation (Å)
8
Half-sphere exposure sum ?
79
Minimum pKa ?
12
% buried
92
Peptide accession
P00336
Residue number A
164
Residue number B
294
Peptide name
L-lactate dehydrogenase B chain

Ligandability

Cysteine 164 of L-lactate dehydrogenase B chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 294 of L-lactate dehydrogenase B chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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