a tool for identifying drug-targetable redox-active disulphides

Phosphoglycerate kinase 2

Intramolecular

Cysteine 379 and cysteine 380

A redox-regulated disulphide may form within Phosphoglycerate kinase 2 between cysteines 379 and 380 (378 and 379 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

51

PDB code

Structure name

crystal structure of phosphoglycerate kinase-2 bound to 3- phosphoglycerate

Structure deposition date

2007-03-26

Thiol separation (Å)

7

Half-sphere exposure sum ?

70

Minimum pK_a ?

11

% buried

70

Peptide accession

Residue number A

379

Residue number B

380

Peptide name

Phosphoglycerate kinase 2

Ligandability

Cysteine 379 of Phosphoglycerate kinase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 380 of Phosphoglycerate kinase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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