ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Asialoglycoprotein receptor 1

Intramolecular
Cysteine 154 and cysteine 165
Cysteine 182 and cysteine 277
Cysteine 255 and cysteine 269
Cysteine 153 and cysteine 154
Cysteine 153 and cysteine 165
A redox-regulated disulphide may form within Asialoglycoprotein receptor 1 between cysteines 154 and 165 (153 and 164 respectively in this structure).

Details

Redox score ?
86
PDB code
5jq1
Structure name
efficient targeting of the asialoglycoprotein receptor by polyvalent display of a compact galactosamine mimic
Structure deposition date
2016-05-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
P07306
Residue number A
154
Residue number B
165
Peptide name
Asialoglycoprotein receptor 1

Ligandability

Cysteine 154 of Asialoglycoprotein receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 165 of Asialoglycoprotein receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Asialoglycoprotein receptor 1 between cysteines 182 and 277 (181 and 276 respectively in this structure).

Details

Redox score ?
81
PDB code
1dv8
Structure name
crystal structure of the carbohydrate recognition domain of the h1 subunit of the asialoglycoprotein receptor
Structure deposition date
2000-01-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
P07306
Residue number A
182
Residue number B
277
Peptide name
Asialoglycoprotein receptor 1

Ligandability

Cysteine 182 of Asialoglycoprotein receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 277 of Asialoglycoprotein receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Asialoglycoprotein receptor 1 between cysteines 255 and 269 (254 and 268 respectively in this structure).

Details

Redox score ?
78
PDB code
5jpv
Structure name
efficient targeting of the asialoglycoprotein receptor by polyvalent display of a compact galactoseamine mimic
Structure deposition date
2016-05-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide accession
P07306
Residue number A
255
Residue number B
269
Peptide name
Asialoglycoprotein receptor 1

Ligandability

Cysteine 255 of Asialoglycoprotein receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 269 of Asialoglycoprotein receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Asialoglycoprotein receptor 1 between cysteines 153 and 154 (152 and 153 respectively in this structure).

Details

Redox score ?
61
PDB code
5jq1
Structure name
efficient targeting of the asialoglycoprotein receptor by polyvalent display of a compact galactosamine mimic
Structure deposition date
2016-05-04
Thiol separation (Å)
7
Half-sphere exposure sum ?
40
Minimum pKa ?
9
% buried
nan
Peptide accession
P07306
Residue number A
153
Residue number B
154
Peptide name
Asialoglycoprotein receptor 1

Ligandability

Cysteine 153 of Asialoglycoprotein receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 154 of Asialoglycoprotein receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Asialoglycoprotein receptor 1 between cysteines 153 and 165 (152 and 164 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
5jq1
Structure name
efficient targeting of the asialoglycoprotein receptor by polyvalent display of a compact galactosamine mimic
Structure deposition date
2016-05-04
Thiol separation (Å)
9
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P07306
Residue number A
153
Residue number B
165
Peptide name
Asialoglycoprotein receptor 1

Ligandability

Cysteine 153 of Asialoglycoprotein receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 165 of Asialoglycoprotein receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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