Alcohol dehydrogenase 1A
Intermolecular
Cysteine 101 and cysteine 287
Intramolecular
Cysteine 101 and cysteine 104
Cysteine 98 and cysteine 101
Cysteine 101 and cysteine 112
Cysteine 98 and cysteine 104
Cysteine 98 and cysteine 112
Cysteine 104 and cysteine 112
Cysteine 47 and cysteine 175
Cysteine 196 and cysteine 212
Cysteine 282 and cysteine 283
More...Cysteine 283 and cysteine 287
Cysteine 10 and cysteine 133
1u3t A 100 B 286
A redox-regulated disulphide may form between two units of Alcohol dehydrogenase 1A at cysteines 101 and 287 (100 and 286 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
1u3t
Structure name
crystal structure of human alcohol dehydrogenase alpha-alpha isoform complexed with n-cyclopentyl-n-cyclobutylformamide determined to 2
Structure deposition date
2004-07-23
Thiol separation (Å)
10
Half-sphere exposure sum ?
66
Minimum pKa ?
6
% buried
54
Peptide A name
Alcohol dehydrogenase 1A
Peptide B name
Alcohol dehydrogenase 1A
Peptide A accession
P07327
Peptide B accession
P07327
Peptide A residue number
101
Peptide B residue number
287
Ligandability
Cysteine 101 of Alcohol dehydrogenase 1A
Cysteine 287 of Alcohol dehydrogenase 1A
1hso B 100 B 103
A redox-regulated disulphide may form within Alcohol dehydrogenase 1A between cysteines 101 and 104 (100 and 103 respectively in this structure).
Details
Redox score ?
88
PDB code
1hso
Structure name
human alpha alcohol dehydrogenase (adh1a)
Structure deposition date
2000-12-27
Thiol separation (Å)
3
Half-sphere exposure sum ?
51
Minimum pKa ?
6
% buried
34
Peptide accession
P07327
Residue number A
101
Residue number B
104
Peptide name
Alcohol dehydrogenase 1A
Ligandability
Cysteine 101 of Alcohol dehydrogenase 1A
Cysteine 104 of Alcohol dehydrogenase 1A
1u3t A 97 A 100
A redox-regulated disulphide may form within Alcohol dehydrogenase 1A between cysteines 98 and 101 (97 and 100 respectively in this structure).
Details
Redox score ?
84
PDB code
1u3t
Structure name
crystal structure of human alcohol dehydrogenase alpha-alpha isoform complexed with n-cyclopentyl-n-cyclobutylformamide determined to 2
Structure deposition date
2004-07-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
51
Minimum pKa ?
6
% buried
27
Peptide accession
P07327
Residue number A
98
Residue number B
101
Peptide name
Alcohol dehydrogenase 1A
Ligandability
Cysteine 98 of Alcohol dehydrogenase 1A
Cysteine 101 of Alcohol dehydrogenase 1A
1hso B 100 B 111
A redox-regulated disulphide may form within Alcohol dehydrogenase 1A between cysteines 101 and 112 (100 and 111 respectively in this structure).
Details
Redox score ?
82
PDB code
1hso
Structure name
human alpha alcohol dehydrogenase (adh1a)
Structure deposition date
2000-12-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
61
Minimum pKa ?
6
% buried
45
Peptide accession
P07327
Residue number A
101
Residue number B
112
Peptide name
Alcohol dehydrogenase 1A
Ligandability
Cysteine 101 of Alcohol dehydrogenase 1A
Cysteine 112 of Alcohol dehydrogenase 1A
1hso A 97 A 103
A redox-regulated disulphide may form within Alcohol dehydrogenase 1A between cysteines 98 and 104 (97 and 103 respectively in this structure).
Details
Redox score ?
78
PDB code
1hso
Structure name
human alpha alcohol dehydrogenase (adh1a)
Structure deposition date
2000-12-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
58
Minimum pKa ?
8
% buried
32
Peptide accession
P07327
Residue number A
98
Residue number B
104
Peptide name
Alcohol dehydrogenase 1A
Ligandability
Cysteine 98 of Alcohol dehydrogenase 1A
Cysteine 104 of Alcohol dehydrogenase 1A
1hso B 97 B 111
A redox-regulated disulphide may form within Alcohol dehydrogenase 1A between cysteines 98 and 112 (97 and 111 respectively in this structure).
Details
Redox score ?
76
PDB code
1hso
Structure name
human alpha alcohol dehydrogenase (adh1a)
Structure deposition date
2000-12-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
67
Minimum pKa ?
8
% buried
44
Peptide accession
P07327
Residue number A
98
Residue number B
112
Peptide name
Alcohol dehydrogenase 1A
Ligandability
Cysteine 98 of Alcohol dehydrogenase 1A
Cysteine 112 of Alcohol dehydrogenase 1A
1u3t B 103 B 111
A redox-regulated disulphide may form within Alcohol dehydrogenase 1A between cysteines 104 and 112 (103 and 111 respectively in this structure).
Details
Redox score ?
75
PDB code
1u3t
Structure name
crystal structure of human alcohol dehydrogenase alpha-alpha isoform complexed with n-cyclopentyl-n-cyclobutylformamide determined to 2
Structure deposition date
2004-07-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
69
Minimum pKa ?
10
% buried
52
Peptide accession
P07327
Residue number A
104
Residue number B
112
Peptide name
Alcohol dehydrogenase 1A
Ligandability
Cysteine 104 of Alcohol dehydrogenase 1A
Cysteine 112 of Alcohol dehydrogenase 1A
1hso B 46 B 174
A redox-regulated disulphide may form within Alcohol dehydrogenase 1A between cysteines 47 and 175 (46 and 174 respectively in this structure).
Details
Redox score ?
71
PDB code
1hso
Structure name
human alpha alcohol dehydrogenase (adh1a)
Structure deposition date
2000-12-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
93
Minimum pKa ?
6
% buried
100
Peptide accession
P07327
Residue number A
47
Residue number B
175
Peptide name
Alcohol dehydrogenase 1A
Ligandability
Cysteine 47 of Alcohol dehydrogenase 1A
Cysteine 175 of Alcohol dehydrogenase 1A
1hso B 195 B 211
A redox-regulated disulphide may form within Alcohol dehydrogenase 1A between cysteines 196 and 212 (195 and 211 respectively in this structure).
Details
Redox score ?
69
PDB code
1hso
Structure name
human alpha alcohol dehydrogenase (adh1a)
Structure deposition date
2000-12-27
Thiol separation (Å)
3
Half-sphere exposure sum ?
97
Minimum pKa ?
9
% buried
95
Peptide accession
P07327
Residue number A
196
Residue number B
212
Peptide name
Alcohol dehydrogenase 1A
Ligandability
Cysteine 196 of Alcohol dehydrogenase 1A
Cysteine 212 of Alcohol dehydrogenase 1A
1u3t B 281 B 282
A redox-regulated disulphide may form within Alcohol dehydrogenase 1A between cysteines 282 and 283 (281 and 282 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
49
PDB code
1u3t
Structure name
crystal structure of human alcohol dehydrogenase alpha-alpha isoform complexed with n-cyclopentyl-n-cyclobutylformamide determined to 2
Structure deposition date
2004-07-23
Thiol separation (Å)
6
Half-sphere exposure sum ?
91
Minimum pKa ?
10
% buried
100
Peptide accession
P07327
Residue number A
282
Residue number B
283
Peptide name
Alcohol dehydrogenase 1A
Ligandability
Cysteine 282 of Alcohol dehydrogenase 1A
Cysteine 283 of Alcohol dehydrogenase 1A
1u3t A 282 A 286
A redox-regulated disulphide may form within Alcohol dehydrogenase 1A between cysteines 283 and 287 (282 and 286 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
1u3t
Structure name
crystal structure of human alcohol dehydrogenase alpha-alpha isoform complexed with n-cyclopentyl-n-cyclobutylformamide determined to 2
Structure deposition date
2004-07-23
Thiol separation (Å)
8
Half-sphere exposure sum ?
89
Minimum pKa ?
10
% buried
90
Peptide accession
P07327
Residue number A
283
Residue number B
287
Peptide name
Alcohol dehydrogenase 1A
Ligandability
Cysteine 283 of Alcohol dehydrogenase 1A
Cysteine 287 of Alcohol dehydrogenase 1A
1u3t A 9 A 132
A redox-regulated disulphide may form within Alcohol dehydrogenase 1A between cysteines 10 and 133 (9 and 132 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
1u3t
Structure name
crystal structure of human alcohol dehydrogenase alpha-alpha isoform complexed with n-cyclopentyl-n-cyclobutylformamide determined to 2
Structure deposition date
2004-07-23
Thiol separation (Å)
10
Half-sphere exposure sum ?
56
Minimum pKa ?
11
% buried
55
Peptide accession
P07327
Residue number A
10
Residue number B
133
Peptide name
Alcohol dehydrogenase 1A
Ligandability
Cysteine 10 of Alcohol dehydrogenase 1A
Cysteine 133 of Alcohol dehydrogenase 1A
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