ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Tyrosine-protein kinase Fes/Fps

Intramolecular
Cysteine 781 and cysteine 785
Cysteine 678 and cysteine 679
A redox-regulated disulphide may form within Tyrosine-protein kinase Fes/Fps between cysteines 781 and 785.

Details

Redox score ?
72
PDB code
4e93
Structure name
crystal structure of human feline sarcoma viral oncogene homologue (v- fes)in complex with tae684
Structure deposition date
2012-03-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
55
Minimum pKa ?
10
% buried
41
Peptide accession
P07332
Residue number A
781
Residue number B
785
Peptide name
Tyrosine-protein kinase Fes/Fps

Ligandability

Cysteine 781 of Tyrosine-protein kinase Fes/Fps

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 785 of Tyrosine-protein kinase Fes/Fps

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tyrosine-protein kinase Fes/Fps between cysteines 678 and 679. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
3bkb
Structure name
crystal structure of human feline sarcoma viral oncogene homologue (v- fes)
Structure deposition date
2007-12-06
Thiol separation (Å)
9
Half-sphere exposure sum ?
63
Minimum pKa ?
10
% buried
46
Peptide accession
P07332
Residue number A
678
Residue number B
679
Peptide name
Tyrosine-protein kinase Fes/Fps

Ligandability

Cysteine 678 of Tyrosine-protein kinase Fes/Fps

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 679 of Tyrosine-protein kinase Fes/Fps

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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