ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Macrophage colony-stimulating factor 1 receptor

Intramolecular
Cysteine 434 and cysteine 441
Cysteine 42 and cysteine 84
Cysteine 419 and cysteine 485
Cysteine 224 and cysteine 278
Cysteine 127 and cysteine 177
Cysteine 127 and cysteine 177
Cysteine 666 and cysteine 667
A redox-regulated disulphide may form within Macrophage colony-stimulating factor 1 receptor between cysteines 434 and 441.

Details

Redox score ?
85
PDB code
4liq
Structure name
structure of the extracellular domain of human csf-1 receptor in complex with the fab fragment of rg7155
Structure deposition date
2013-07-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
P07333
Residue number A
434
Residue number B
441
Peptide name
Macrophage colony-stimulating factor 1 receptor

Ligandability

Cysteine 434 of Macrophage colony-stimulating factor 1 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 441 of Macrophage colony-stimulating factor 1 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Macrophage colony-stimulating factor 1 receptor between cysteines 42 and 84.

Details

Redox score ?
84
PDB code
4liq
Structure name
structure of the extracellular domain of human csf-1 receptor in complex with the fab fragment of rg7155
Structure deposition date
2013-07-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
P07333
Residue number A
42
Residue number B
84
Peptide name
Macrophage colony-stimulating factor 1 receptor

Ligandability

Cysteine 42 of Macrophage colony-stimulating factor 1 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 84 of Macrophage colony-stimulating factor 1 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Macrophage colony-stimulating factor 1 receptor between cysteines 419 and 485.

Details

Redox score ?
82
PDB code
4wrm
Structure name
structure of the human csf-1:csf-1r complex
Structure deposition date
2014-10-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
P07333
Residue number A
419
Residue number B
485
Peptide name
Macrophage colony-stimulating factor 1 receptor

Ligandability

Cysteine 419 of Macrophage colony-stimulating factor 1 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 485 of Macrophage colony-stimulating factor 1 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Macrophage colony-stimulating factor 1 receptor between cysteines 224 and 278.

Details

Redox score ?
81
PDB code
4dkd
Structure name
crystal structure of human interleukin-34 bound to human csf-1r
Structure deposition date
2012-02-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
P07333
Residue number A
224
Residue number B
278
Peptide name
Macrophage colony-stimulating factor 1 receptor

Ligandability

Cysteine 224 of Macrophage colony-stimulating factor 1 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 278 of Macrophage colony-stimulating factor 1 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Macrophage colony-stimulating factor 1 receptor between cysteines 127 and 177.

Details

Redox score ?
79
PDB code
3ejj
Structure name
structure of m-csf bound to the first three domains of fms
Structure deposition date
2008-09-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide accession
P09581
Residue number A
127
Residue number B
177
Peptide name
Macrophage colony-stimulating factor 1 receptor

Ligandability

Cysteine 127 of Macrophage colony-stimulating factor 1 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 177 of Macrophage colony-stimulating factor 1 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Macrophage colony-stimulating factor 1 receptor between cysteines 127 and 177.

Details

Redox score ?
79
PDB code
4wrl
Structure name
structure of the human csf-1:csf-1r complex
Structure deposition date
2014-10-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
85
Minimum pKa ?
nan
% buried
nan
Peptide accession
P07333
Residue number A
127
Residue number B
177
Peptide name
Macrophage colony-stimulating factor 1 receptor

Ligandability

Cysteine 127 of Macrophage colony-stimulating factor 1 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 177 of Macrophage colony-stimulating factor 1 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Macrophage colony-stimulating factor 1 receptor between cysteines 666 and 667. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
3lcd
Structure name
inhibitor bound to a dfg-in structure of the kinase domain of csf-1r
Structure deposition date
2010-01-10
Thiol separation (Å)
8
Half-sphere exposure sum ?
56
Minimum pKa ?
10
% buried
50
Peptide accession
P07333
Residue number A
666
Residue number B
667
Peptide name
Macrophage colony-stimulating factor 1 receptor

Ligandability

Cysteine 666 of Macrophage colony-stimulating factor 1 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 667 of Macrophage colony-stimulating factor 1 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: