a tool for identifying drug-targetable redox-active disulphides

Adenine phosphoribosyltransferase

Intramolecular

Cysteine 140 and cysteine 153 L

A redox-regulated disulphide may form within Adenine phosphoribosyltransferase between cysteines 140 and 153.

Details

Redox score ?

71

PDB code

Structure name

crystal structure of human aprt wild type in complex with hypoxanthine, prpp and mg2+

Structure deposition date

2018-08-23

Thiol separation (Å)

4

Half-sphere exposure sum ?

88

Minimum pK_a ?

8

% buried

90

Peptide accession

Residue number A

140

Residue number B

153

Peptide name

Adenine phosphoribosyltransferase

Ligandability

Cysteine 140 of Adenine phosphoribosyltransferase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 153 of Adenine phosphoribosyltransferase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: